| 不同化学发光分析系统对乙型肝炎血清标志物检测的比较 |
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| 引用本文： | 谢而付,蒋 理,刘雁雁,张巧娣,凌 芸,潘世扬.不同化学发光分析系统对乙型肝炎血清标志物检测的比较[J].南京医科大学学报,2012(4):582-584. |
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| 作者姓名： | 谢而付 蒋 理 刘雁雁 张巧娣 凌 芸 潘世扬 |
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| 作者单位： | 南京医科大学第一附属医院医学检验科,江苏 南京 210029;南京医科大学第一附属医院医学检验科,江苏 南京 210029;南京医科大学第一附属医院医学检验科,江苏 南京 210029;南京医科大学第一附属医院医学检验科,江苏 南京 210029;南京医科大学第一附属医院医学检验科,江苏 南京 210029;南京医科大学第一附属医院医学检验科,江苏 南京 210029 |
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| 基金项目： | 江苏省实验诊断学重点实验室基金资助(XK201114);国家自然科学基金资助(81101322);江苏省高校优势学科建设工程资助项目 |
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| 摘 要： | 目的:对Roche Cobas e601和Abott Architect i2000 分析系统检测主要乙型肝炎血清标志物HBsAg?抗-HBs和HBeAg的结果符合性和相关性进行评价?方法:分别采用两种分析系统对119份?140份?197份标本的HBsAg?抗-HBs和HBeAg进行检测?结果:两种分析系统对HBsAg?抗-HBs?HBeAg检测的定性结果符合率分别为99.1%?95.7%和90.9%,定量数值的相关系数分别为0.566?0.863?0.964,其中抗-HBs浓度存在显著差异(P < 0.05),Abott Architect i2000显著高于Roche Cobas e 601分析系统?结论:两种分析系统在乙型肝炎标志物的定性结果判断中具有较好的符合率,但抗-HBs浓度之间存在差异?
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| 关 键 词： | 化学发光分析系统 乙型肝炎血清标志物 方法学比较 |
| 收稿时间： | 2011/11/3 0:00:00 |
A comparison of HBV seromarkers by two different chemiluminescence immunoassay systems |
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| XIE Er-fu,JIANG Li,LIU Yan-yan,ZHANG Qiao-di,LING Yun and PAN Shi-yang.A comparison of HBV seromarkers by two different chemiluminescence immunoassay systems[J].Acta Universitatis Medicinalis Nanjing,2012(4):582-584. |
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| Authors: | XIE Er-fu JIANG Li LIU Yan-yan ZHANG Qiao-di LING Yun and PAN Shi-yang |
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| Institution: | Department of Laboratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Laboratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Laboratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Laboratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Laboratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of Laboratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China |
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| Abstract: | Objective:To analyze the concordance and correlation of the detection results of HBsAg,anti-HBs and HBeAg,which were measured by Roche Cobas e601 and Abott Architect i2000,respectively. Methods:The serum samples,including 119 for HBsAg detection,140 for anti-HBs detection and 197 for HBeAg detection,were differently measured by these two chemiluminescence immunoassay(CLIA) systems. Results:The concordance of qualitative results for HBsAg,anti-HBs and HBeAg were 99.1%,95.7% and 90.9% between these two CLIA systems,and the correlation coefficient of quantitative results were 0.566,0.863 and 0.964. But the anti-HBs concentration measured by Abott Architect i 2000 was significantly higher than that of Roche Cobas e 601 system. Conclusion:Qualitative detection results of HBV markers in serum measured by these two systems have good concordance,but anti-HBs concentrations detected were significant different between these two systems. |
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| Keywords: | chemiluminescence immunoassay systems HBV serum markers methods comparison |
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