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P300 latency reflects the degree of cognitive decline in dementing illness
Authors:J Polich  C L Ehlers  S Otis  A J Mandell  F E Bloom
Affiliation:1. Division of Preclinical Neuroscience and Endocrinology, La Jolla, CA 92037, U.S.A.;2. Division of Neurology, Scripps Clinic and Research Foundation, La Jolla, CA 92037, U.S.A.;3. Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 U.S.A.;1. Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE, USA;2. University of Northern Colorado, Greeley, CO, USA;1. Department of Urology, Loyola University Medical Center, Maywood, IL, USA;2. 1:MAP Surgical Analytics Group, Loyola University Medical Center, Maywood, IL, USA;3. Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA;4. Department of Surgery, Loyola University Medical Center, Maywood, IL, USA;1. Laboratoire de Psychologie Médicale et d’Addictologie, ULB Neuroscience Institute (UNI), CHU Brugmann-Université Libre de Bruxelles (U.L.B.), Belgium;2. Zentrum für Psychiatrie Justus-Liebig-Universität Gießen, Germany
Abstract:An auditory discrimination paradigm was employed to elicit the P3 component of the event-related brain potential (ERP) from 39 demented patients (mean age = 71 years). Component latency was longer in patients who were diagnosed as having primary degenerative dementia and other cognitive impairment disorders compared to age-matched controls. Neurologist ratings of cognitive impairment were significantly correlated with P3 latency values, although no differences in mean latency were obtained between the various categories of dementia. ERP measurement techniques and the interpretation of P3 latency as in index of dementing illness are discussed.
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