Changes in muscle blood flow after smoking a cigarette determined by a new noninvasive method |
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Authors: | F Weber M Anlauf R -D Müller |
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Institution: | (1) Department of Pharmaceutical Services, Kumamoto University Hospital, Kumamoto, Japan;(2) Third Department of Internal Medicine, Kumamoto University Medical School, Kumamoto, Japan;(3) Kumamoto Regional Medical Center, Kumamoto, Japan;(4) Department of Drug Metabolism, Yamanouchi Pharmaceutical Co., Tokyo, Japan |
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Abstract: | Summary The pharmacokinetics of the H2-receptor antagonist famotidine, after oral administration of a 20 mg tablet, has been studied in 10 elderly patients with normal renal function (CLCR 59 ml·min–1, Mean=80 ml·min–1), 5 elderly patients with renal insufficiency (CLCR 38 ml·min–1, Mean=15 ml·min–1), and 6 healthy young volunteers.Elimination half-life in the elderly patients with renal insufficiency was significantly prolonged compared to the elderly patients with normal renal function and the young volunteers. The correlation coefficient between creatinine clearance and the elimination rate constant of famotidine was 0.672. Mean urinary recovery of unchanged drug up to 24 h in the young volunteers was 44%. The mean renal clearance of famotidine in the young volunteers (270 ml·min–1) was substantially greater than the creatinine clearance, 128 ml·min–1, which suggests the possibility of tubular secretion of famotidine. |
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Keywords: | famotidine H2-receptor antagonist renal insufficiency old age pharmacokinetics |
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