嗅觉功能检测对阿尔茨海默病的早期诊断价值

目的探讨嗅觉功能检测对阿尔茨海默病（AD）的早期诊断价值。方法用图片介导的气味识别试验分别检测21例AD患者（AD组）及21例健康体检者（对照组）的嗅觉察觉阈、嗅觉识别阈，并分析其与简易智能状态检查（MMSE）之间的相关性。结果AD组患者有不同程度的嗅觉障碍，嗅觉察觉阈（1．81±0．75）分，嗅觉识别阈（2．48±0．68）分，均高于对照组的（1．24±0．89）分和（2．00±0．71）分，差异有统计学意义（P〈0．05）。AD组MMSE评分与嗅觉察觉阈、嗅觉识别阈呈负相关、（r=-0．50、-0．54，P〈0．01）。结论嗅觉功能检测可帮助诊断早期AD，单独采用此方法存在一定的局限性，应与其他方法联合诊断早期AD。

The maternal and neonatal effect of fentanil used in general anesthesia induction for cesarean section

Objective To observe the effect of general anesthesia induction with fentanil on parturient undergoing cessrean section and Apgar score of newborn. Methods Forty-two example cesarean section under general anesthesia were induced with fentanil 4μ/kg, propofol 1.5-2.0 mg/kg, atracurium 0.5mg/kg.Observed the change of hemodynamics parameter of parturientand 1 min,5 min Apgar score of newborn. Results Parturient woman blood stream dynamics Was stable. The premature delivery, the low body weight, the polyembryony or the anaesthesia had used the hypnotics group, its newborn 1 min Apgar score was obviously lower than that had not merged above situations(P＜0.01),but the newborn 5 min Apgar score was not significantly different(P＞0.05).Conclusions Fentanil used in cesarean section general anesthesia induction, parturient woman blood stream dynamics is stable, affects not obviously to newborn's Apgar scoure. But regarding the premature delivery, the polyembryony, the low body weight or the pregnant woman used the hypnotics, cegaresn section general anesthesia induction with fentanil should be supposed to use cautiously.