| 生物活性物质对蟾蜍心脏的双重作用 |
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| 引用本文： | 张甫同,张文惠. 生物活性物质对蟾蜍心脏的双重作用[J]. 中国药理学通报, 1989, 0(2) |
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| 作者姓名： | 张甫同 张文惠 |
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| 作者单位： | [1]皖南医学院生理学教研室 [2]皖南医学院生理学教研室 芜湖 |
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| 摘 要： | 在离体蟾蜍心脏上,研究生物活性物质(NE,ACh,CaCl_2,KCl)的量—效关系。发现在不同浓度阻断剂影响下,上述药物均呈现双重作用。当阻断α和(或)β受体时,其正性变力性作用被阻抑而呈现负性作用,阻断M_1、M_2和(或)Cl~-通道时,其负性变力性作用翻转为正性作用。
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| 关 键 词： | 去甲肾上腺素 乙酰胆碱CaCl_2 KCl 正性和负性变 力性作用 翻转 |
BIPHASIC ACTION OF BIOTIC ACTIVITOR ON TOAD HEART |
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| Abstract: | The dose-response reaction of NE, ACh, CaCl2 & KC1 was observed in isolated toad hearts. When the above substances in different concentrations were employed, or the hearts were affected by difference blockers, a biphasic action could be observed. The positive inotropic effect of the substance was inhibited with the presentation of negative inotropic eff ect ,if α &(or) β receptor were blocked. The negative inotropic effect of the substance changed into positive, when M1, M2 receptor &(or) Cl- channel were blocked. |
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| Keywords: | Norepinephrine Acetylcholine Potassium chloride Calcium chloride Positive & negative inotropic effect Reverse. |
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