| 10－羟基－2－癸烯酸对荷瘤小鼠的抑瘤作用及免疫增强作用 |
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| 引用本文： | 王国燕,林志彬.10－羟基－2－癸烯酸对荷瘤小鼠的抑瘤作用及免疫增强作用[J].北京大学学报(医学版),1996(5). |
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| 作者姓名： | 王国燕 林志彬 |
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| 作者单位： | 北京医科大学药理学系，昆明医学院药理教研室 |
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| 摘 要： | 目的：观察１０－羟基－２－癸烯酸（１０－ＨＤＡ）对荷瘤小鼠的抑瘤作用及免疫功能的影响。方法：接种Ｓ１８０小鼠的瘤重、接种艾氏腹水癌小鼠的生存期及因荷瘤而降低的迟发型超敏反应为指标，观察腹腔注射１０－ＨＤＡ的作用。结果：１０－ＨＤＡ明显抑制Ｓ１８０实体瘤生长，延长艾氏腹水癌小鼠生存期，并能恢复小鼠因荷瘤而降低的迟发型超敏反应。结论：腹腔注射１０－ＨＤＡ对小鼠Ｓ１８０实体瘤及艾氏腹水癌具有抑瘤作用，并能恢复因荷瘤所致的免疫功能低下，后者可能与其体内抗肿瘤作用有关。
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| 关 键 词： | 10－羟基－2－癸烯酸／药理学 肉瘤180／药物疗法 癌／Ehrlich瘤 超敏感性，迟发型／药物疗法 |
ANTITUMOR AND IMMUNOPOTENTIATING EFFECT OF10-HYDROXY-2-DECENOIC ACID ONTUMOR-BEARING MICE |
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| WANG Guoyan,LIN Zhibin.ANTITUMOR AND IMMUNOPOTENTIATING EFFECT OF10-HYDROXY-2-DECENOIC ACID ONTUMOR-BEARING MICE[J].Journal of Peking University:Health Sciences,1996(5). |
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| Authors: | WANG Guoyan LIN Zhibin |
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| Abstract: | Objective:The effect of 10-Hydroxy-2-decenoic acid(10-HDA),unsaturated fatty acid ex-tracted from royal jelly,on tumor and immune function was studied in tumor-bearing mice,Methods:The effect of 10-HDA ip on the weight of tumor,survival time and delayed type hypersensitivity(DTH)was observed in S180 or EVC bearing mice. Results:10-HDA significantly decreased tumor weight in S180-bearing mice,prolonged the survival time in EAC-bearing mice and restored the de-creased DTH in both kinds of tumor bearing mice. Conclusion:These results indicate that 10-HDA ip had antitumor and immunopotentiating effects,the latter may involve the antitumor activity of 10-HDA |
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| Keywords: | Hydroxy-2-decenoic acid/pharmacol Sarcoma 180/drug ther Carcinoma/Ehrlich tu-mor Hypersensitivity delayed/durg ther |
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