Advanced-glycation end products in insulin-resistant states |
| |
Authors: | Georgia Soldatos Mark E. Cooper Karin A. M. Jandeleit-Dahm |
| |
Affiliation: | (1) Baker Heart Research Institute, Commercial Road, 3181 Melbourne, Victoria, Australia |
| |
Abstract: | Insulin resistance is a central component of a number of clinical conditions, including the metabolic syndrome, diabetes, and hypertension. There is emerging evidence that the consequent hyperinsulinemia and visceral adiposity may be directly responsible for the excess cardiovascular morbidity and mortality seen in these conditions. Advanced-glycation end products, a chemically diverse group of compounds found in higher levels in insulin-resistant states, have also been shown to adversely affect endothelial function as well as activate numerous intracellular signaling pathways implicated in the atherosclerotic pathway. In this review, we summarize the factors thought to be important in both the initiation and exacerbation of the insulin-resistant state, and directly examine the potential role of advanced-glycation end products in this process. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|