复方甘草甜素合用促肝细胞生长素抗肝纤维化的疗效观察

目的探讨复方甘草甜素合用促肝细胞生长素抗肝纤维化作用。方法80例慢性乙型肝炎患者,分复方甘草甜素合用促肝细胞生长素组(联合治疗组)、复方甘草甜素组、促肝细胞生长素(pHGF组)及对照组。治疗前后检测肝功能及肝纤维化血清学指标透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层黏蛋白(LN)及IV型胶原(IV-C)。结果治疗后各组肝功能指标丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)均较治疗前明显改善(P<0.05)。联合治疗组、复方甘草甜素组、pHGF组ALT、AST、ALB优于对照组(P<0.05);联合治疗组ALT、AST、ALB较复方甘草甜素组、pHGF组明显改善(P<0.05)。治疗后各治疗组HA、PCⅢ、IV-C、LN均较治疗前明显降低(P<0.05);治疗后联合治疗组、复方甘草甜素组、pHGF组HA、PCⅢ、IV-C、LN低于对照组(P<0.05);联合治疗组HA、PCⅢ、IV-C、LN较复方甘草甜素组、pHGF组明显改善(P<0.05)。结论复方甘草甜素和pHGF抗肝纤维化效果相似,但联合用药效果更好。

Combining compound glycyrrhizin with hepatocyte growth-promoting factors for treatment of hepatic fibrosis

Objective To study the effect of compound glycyrrhizin and hepatocyte growth-promoting factors(pHGF) in treatment of hepatic fibrosis.Methods Eighty cases of chronic hepatitis B were randomly divided into combination group,compound glycyrrhizin group,pHGF group and control group.The hepatic function and hyaluronic acid(HA),precollagen Ⅲ(PCⅢ),laminin(LN) and collogen IV were detected pre-and post-treatment.Results ALT、AST and ALB were improved post-treatment in every treatment groups(P<0.05).ALT、AST and ALB were better in combination group,compound glycyrrhizin group and pHGF group than these in the control group(P<0.05).ALT、AST and ALB wer more improved in combination group than these in compound glycyrrhizin group and pHGF group(P<0.05).Compared with pre-treatment,HA、PCⅢ、collogen IV and LN were lower post-treatment in every treatment group(P<0.05).HA、PCⅢ、collogen IV and LN were lower in combination group,compound glycyrrhizin group and pHGF group than these in control group(P<0.05).HA、PCⅢ、collogen IV and LN were lower in combination group than these in compound glycyrrhizin group and pHGF group(P<0.05).Conclusion The effect of both compound glycyrrhizin and pHGF in treatment of hepatic fibrosis is similar,but the effect of therapeutic alliance is more better.