大蒜素保留灌肠治疗溃疡性结肠炎临床研究

目的观察大蒜素保留灌肠在溃疡性结肠炎治疗中的疗效,副作用及半年复发率。方法随机将溃疡性结肠炎患者分为两组,治疗组50例,给大蒜素液40 mg,山莨菪碱10 mg,生理盐水100 ml,保留灌肠,每晚睡前1次;对照组40例,给予柳氮磺胺吡啶1 g,4次/d,复方谷氨酰胺0.2 g,3次/d,餐后服用。均治疗4周。治疗4周后复查有关生化指标,血尿便三大常规及肠镜,并随访半年。结果显效率、总有效率及半年复发率,治疗组分别为48.0%,86.0%和18.0%;对照组分别为30.0%,72.5%,35.0%。治疗组未见明显副反应,对照组副反应有白细胞轻度减少3例(7.5%),胃肠道反应9例(25.0%)。结论大蒜素保留灌肠能有效治疗溃疡性结肠炎,且副作用少,复发率低。

Clinical Study of Garlicin on Patients with Ulcerative Colitis

Objective To investigate the clinical efficacy of garlicin retention enema on the patientse with ulcerative colitis,as well as the adverse effect and the half-year relapse.Methods Ninety patients with ulcerative colitis were divided into trial group(n=50) and control group(n=40) at random.The patients in the trial group were treated by retention enema with garlicin(40 mg) once per night,while the patients in the control group were treated by 1 g of salicylazesulfapyridine four times a day and 200 mg of glut...