Studies on Glycoproteins and Glycopeptides from Tn-Polyagglutinable Erythrocytes |
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| Authors: | Dr. W. Dahr G. Uhlenbruck H. H. Gunson M. van der Hart |
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| Affiliation: | Medical University Clinic, Cologne, Regional Blood Transfusion Service, Lancaster;Central Laboratory of the Netherlands Red Cross Transfusion Service, Amsterdam |
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| Abstract: | Abstract. Direct evidence for the theory that Tn-polyagglutinable erythrocytes have a deficiency of alkali-labile sialic acid and galactose is gained by analysing the carbohydrate moiety of the tryptic glycopeptides with spectrophotometric methods and gas-liquid chromatography. Alkaline borohydride treatment of these glycopeptides specifically releases N -acetylgalactosaminitol. In addition it is shown that mainly the third and the first membrane glycoprotein are affected by the defect. |
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