| 肿瘤微环境对肿瘤代谢的影响及研究进展 |
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| 引用本文： | 刘宇佳,张轶雯,钟里科. 肿瘤微环境对肿瘤代谢的影响及研究进展[J]. 肿瘤学杂志, 2020, 26(1): 47-52 |
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| 作者姓名： | 刘宇佳 张轶雯 钟里科 |
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| 作者单位： | 中国科学院肿瘤与基础医学研究所，中国科学院大学附属肿瘤医院，浙江省肿瘤医院,中国科学院肿瘤与基础医学研究所，中国科学院大学附属肿瘤医院，浙江省肿瘤医院,中国科学院肿瘤与基础医学研究所，中国科学院大学附属肿瘤医院，浙江省肿瘤医院 |
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| 基金项目： | 浙江省卫生厅项目（2017RC001；2018257154；2018KY148） |
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| 摘 要： | 肿瘤能量代谢的重要特征为其主要通过糖酵解供能,即众所周知的Warburg效应。肿瘤微环境不仅为肿瘤生长提供能量支持,而且调控肿瘤信号通路,促进肿瘤细胞的增殖、侵袭和转移。全文就肿瘤微环境及其对肿瘤代谢的调控作用进行综述。
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| 关 键 词： | 恶性肿瘤 肿瘤微环境 肿瘤代谢 Warburg效应 |
| 收稿时间： | 2019-05-07 |
Research Progress on Effect of Tumor Environment in Tumor Metabolic |
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| LIU Yu-jia,ZHANG Yi-wen,ZHONG Li-ke,HUANG Ping. Research Progress on Effect of Tumor Environment in Tumor Metabolic[J]. Journal of Chinese Oncology, 2020, 26(1): 47-52 |
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| Authors: | LIU Yu-jia ZHANG Yi-wen ZHONG Li-ke HUANG Ping |
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| Affiliation: | (Institute of Cancer and Basic Medicine,Chinese Academy of Science,Cancer Hospital of the University of Chinese Academy of Science,Zhejiang Cancer Hospital,Hangzhou 310022,China) |
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| Abstract: | Aerobic glycolysis is considered as a key feature of cancer metabolism,which is known as Warburg effect. The tumor environment supplies energy and also modulates signaling pathways in tumor cells and stimulate proliferation,invasion and metastasis. In recent years,tumor microenvironment and metabolism have become a hot spot in tumor research. The role of tumor environment in the tumor metabolism is reviewed in this article. |
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| Keywords: | malignant tumors tumor environment tumor metabolic Warburg effect |
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