加味温经汤联合阿仑膦酸钠片治疗肾阳亏虚型绝经后骨质疏松症临床研究

目的:观察加味温经汤联合阿仑膦酸钠片治疗肾阳亏虚型绝经后骨质疏松症(PMOP)的临床疗效。方法:选取150例肾阳亏虚型PMOP患者,按随机数字表法分为对照组和观察组各75例。对照组给予口服阿仑膦酸钠片治疗,观察组在对照组基础上加服加味温经汤,2组均治疗6个月。对比2组总体疗效、治疗前后碱性磷酸酶(ALP),血钙(Ca)、磷(P),雌二醇(E2),促卵泡雌素(FSH),促黄体生成素(LH)水平,记录治疗过程中不良反应发生情况。结果:观察组总有效率96.0%,对照组总有效率80.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组ALP水平均较治疗前降低(P<0.05),血Ca含量均较治疗前增加(P<0.05);观察组ALP水平低于对照组(P<0.05),血Ca含量高于对照组(P<0.05)。治疗后,2组E2水平均较治疗前升高,FSH及LH水平均较治疗前降低,差异均有统计学意义(P<0.05);观察组E2水平高于对照组,差异有统计学意义(P<0.05)。2组血常规异常、肝肾功能异常、消化道症状、皮肤过敏发生率比较,差异均无统计学意义(P>0.05)。结论:加味温经汤治疗肾阳亏虚型PMOP,能有效改善患者的临床症状和性激素水平,用药安全性高。

Clinical Study of Modified Wenjing Tang Combined with Alendronate Sodium Tablets for Postmenopausal Osteoporosis of Kidney Yang Deficiency Type

Objective:To observe the clinical effect of modified Wenjing tang combined with alendronate sodium tablets for postmenopausal osteoporosis(PMOP)of kidney yang deficiency type.Methods:A total of 150 cases of PMOP patients of kidney yang deficiency type were divided into the control group and the observation group according to the random number table method,75 cases in each group.The control group was given oral administration of alendronate sodium tablets,and the observation group was additionally treated with modified Wenjing tang based on the treatment of the control group.Both groups were treated for six months.The total curative effect,and the levels of alkaline phosphatase(ALP),calcium(Ca),phosphorus(P),estrogen(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)before and after treatment in the two groups were compared;the incidence of adverse reactions during treatment was recorded.Results:The total effective rate was 96.0%in the observation group and 80.0%in the control group,the difference being significant(P<0.05).After treatment,the content of ALP in the two groups was decreased when compared with that before treatment(P<0.05),and Ca in blood in the two groups was increased when compared with that before treatment(P<0.05);the content of ALP in the observation groups was lower than that in the control group(P<0.05),the content of Ca in blood in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of E2 in the two groups were increased when compared with those before treatment,and the levels of FSH and LH were decreased when compared with those before treatment,differences being significant(P<0.05);the level of E2 in the observation group was higher than that in the control group,the difference being significant(P<0.05);compared the incidences of abnormal blood routine,abnormal liver and kidney function,gastrointestinal symptoms and skin allergy in the two groups,there was significance in differences(P>0.05).Conclusion:The therapy of modified Wenjing tang in treating PMOP of kidney yang deficiency type can effectively improve the clinical symptoms and the levels of sex hormones,and with high medication safety.