| 癌症的异质性表征与深度表型 |
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| 引用本文： | Shahin Alam,Adiba Sultan,王 姣,何雪飞,沈百荣. 癌症的异质性表征与深度表型[J]. 中华医学图书情报杂志, 2019, 28(10): 1-6 |
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| 作者姓名： | Shahin Alam Adiba Sultan 王 姣 何雪飞 沈百荣 |
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| 作者单位： | 苏州大学系统生物学研究中心，江苏 苏州 215006,苏州大学系统生物学研究中心，江苏 苏州 215006,四川大学华西医院系统遗传研究院，四川 成都 610041,四川大学华西医院系统遗传研究院，四川 成都 610041,四川大学华西医院系统遗传研究院，四川 成都 610041 |
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| 基金项目： | 国家重点研发计划重点专项“帕金森病生物数据整合和分析”（2016YFC1306605） |
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| 摘 要： | 随着老龄化时代的到来，癌症发病率不断增高，癌症的防治和慢病管理已成为推动社会经济发展的关键因素。生物医学和信息技术的迅猛发展以及主动健康、精准医学和大数据范式的兴起等，为癌症的防治带来新的机遇。从信息学角度探讨了癌症异质性的形成与表征，癌症深度表型挖掘，癌症治疗的组合用药算法，癌症的预防与慢病管理的信息模型、系统与平台等方面的最新研究方向，并对癌症医学信息学领域面临的挑战与机会进行了分析和展望。
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| 关 键 词： | 癌症演化与异质性；深度表型挖掘；协同药物组合；算法与模型 |
| 收稿时间： | 2019-09-16 |
Cancer heterogeneity characterization and deep phenotyping |
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| Shahin Alam,Adiba Sultan,WANG Jiao,HE Xue-fei and SHEN Bai-rong. Cancer heterogeneity characterization and deep phenotyping[J]. Chinese Journal of Medical Library and Information Science, 2019, 28(10): 1-6 |
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| Authors: | Shahin Alam Adiba Sultan WANG Jiao HE Xue-fei SHEN Bai-rong |
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| Affiliation: | Soochow University Systematic Biology Research Center, Suzhou 215006, Jiangsu Province, China,Soochow University Systematic Biology Research Center, Suzhou 215006, Jiangsu Province, China,Sichuan University West China Hospital Systematic Genetics Institute, Chengdu 610041, Sichuan Province, China,Sichuan University West China Hospital Systematic Genetics Institute, Chengdu 610041, Sichuan Province, China and Sichuan University West China Hospital Systematic Genetics Institute, Chengdu 610041, Sichuan Province, China |
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| Abstract: | Prevention and treatment of cancer and management of chronic diseases have become the key factors restricting social and economic development as the incidence of cancer increases with aging. The rapid development of biomedical and information technology, and the emergence of active health, precision medicine and big data paradigms have brought new opportunities for the prevention and treatment of cancer. The recent interests in heterogeneity and exterior syndrome of cancer, mining of deep phenotype of cancer, combined drug use algorithm for cancer treatment, information model of prevention and treatment of cancer and management of chronic diseases, systems and platforms were thus studied in this paper from the angle of informatics, the challenges and opportunities in medical and information field of cancer were analyzed in prospecttive view of point. |
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| Keywords: | Evolution and heterogeneity of cancer Mining of deep phenotype Synergistic drug combination Algorithm and model |
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