| 代谢组学在中药七情配伍中的应用研究进展 |
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| 引用本文： | 马骏,曼琼,邓毅,杨志军,杨秀娟,李鹏杰. 代谢组学在中药七情配伍中的应用研究进展[J]. 中草药, 2020, 51(1): 276-280 |
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| 作者姓名： | 马骏 曼琼 邓毅 杨志军 杨秀娟 李鹏杰 |
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| 作者单位： | 甘肃中医药大学, 甘肃 兰州 730000,甘肃中医药大学, 甘肃 兰州 730000,甘肃中医药大学, 甘肃 兰州 730000;甘肃省中药药理与毒理学重点实验室, 甘肃 兰州 730000,甘肃中医药大学, 甘肃 兰州 730000,甘肃中医药大学, 甘肃 兰州 730000,甘肃中医药大学, 甘肃 兰州 730000 |
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| 基金项目： | 国家自然科学基金（地区）项目（81360633）；兰州市科技局项目（2018-4-63）；甘肃省中药药理与毒理重点实验室开放基金项目（ZDSYS-KJ-2018-009） |
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| 摘 要： | 中药七情是中药配伍的主要形式。代谢组学主要研究代谢谱差异,通过分析代谢物以及代谢通路与生理病理变化的相对关系,阐释药物的作用机制,分析配伍用药的作用关系。通过归纳近年来运用代谢组学分析中药单行、相须、相使、相畏、相杀、相恶、相反7种配伍方式产生的增效、减毒、药性变化及作用机制,为客观地阐释中药七情配伍应用的合理性提供依据。
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| 关 键 词： | 代谢组学 中药七情 配伍 机制 整体观念 增效 减毒 药性变化 |
| 收稿时间： | 2019-08-04 |
Research progress of metabonomics in compatibility of seven emotions of Chinese materia medica |
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| MA Jun,MAN Qiong,DENG Yi,YANG Zhi-jun,YANG Xiu-juan and LI Peng-jie. Research progress of metabonomics in compatibility of seven emotions of Chinese materia medica[J]. Chinese Traditional and Herbal Drugs, 2020, 51(1): 276-280 |
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| Authors: | MA Jun MAN Qiong DENG Yi YANG Zhi-jun YANG Xiu-juan LI Peng-jie |
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| Affiliation: | Gansu University of Traditional Chinese Medicine, Lanzhou 7300000, China,Gansu University of Traditional Chinese Medicine, Lanzhou 7300000, China,Gansu University of Traditional Chinese Medicine, Lanzhou 7300000, China;Gansu Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine, Lanzhou 730000, China,Gansu University of Traditional Chinese Medicine, Lanzhou 7300000, China,Gansu University of Traditional Chinese Medicine, Lanzhou 7300000, China and Gansu University of Traditional Chinese Medicine, Lanzhou 7300000, China |
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| Abstract: | Seven emotions of Chinese materia medica (CMM) is the main compatibility form. Metabonomics is mainly to study the differences of metabolic spectrum, analyze the relationship between pathway and physiological and pathological changes of organisms after drug use through the analysis of metabolites, and explain the mechanism of drug action and the function relationship of compatible drugs. The author summarized the characteristics of increasing efficiency, detoxification, drug property changes and action mechanism from the compatibility forms of using a single drug, mutual reinforcement, mutual assistance, mutual restraint, mutual suppression, mutual inhibition and antagonism in the application of CMM by using metabonomics in recent years, in order to provide a basis for the objective interpretation of the compatibility of seven emotions of CMM. |
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| Keywords: | metabonomics seven emotions of Chinese materia medica compatibility mechanism overall concept increasing efficiency detoxification drug property changes |
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