| 胡芦巴种子化学成分研究 |
| |
| 引用本文： | 刘芬芸,张东丽,侯文彬,唐生安. 胡芦巴种子化学成分研究[J]. 中草药, 2020, 51(1): 31-35 |
| |
| 作者姓名： | 刘芬芸 张东丽 侯文彬 唐生安 |
| |
| 作者单位： | 天津医科大学药学院, 天津市临床药物关键技术重点实验室, 天津 300070;天津市第二人民医院, 天津市肝病医学研究所, 天津 300192,天津医科大学药学院, 天津市临床药物关键技术重点实验室, 天津 300070,北京协和医学院 中国医学科学院放射医学研究所, 天津市放射医学与分子核医学重点实验室, 天津 300192,天津医科大学药学院, 天津市临床药物关键技术重点实验室, 天津 300070 |
| |
| 基金项目： | 天津市自然科学基金重点项目（16JCZDJC32600）；中国博士后基金资助项目（2016M591399） |
| |
| 摘 要： | 目的对胡芦巴Trigonella foenum-graecum的化学成分进行研究。方法运用Sephadex LH-20凝胶、硅胶柱色谱、半制备高效液相色谱等多种色谱技术进行分离和纯化,并通过其理化性质和NMR数据综合分析,鉴定化合物结构。结果从胡芦巴乙醇提取物中得到6个甾体皂苷类和黄酮类化合物,分别为22-甲氧基-胡芦巴皂苷Ⅱb(1)、芰脱皂苷元(2)、薯蓣皂苷元(3)、木犀草素(4)、木犀草苷(5)、木犀草素-7-O-芸香糖苷(6)。结论化合物1为新化合物,化合物5和6是从该植物中首次分离得到。
|
| 关 键 词： | 胡芦巴 甾体皂苷 22-甲氧基-胡芦巴皂苷IIb 木犀草苷 木犀草素-7-O-芸香糖苷 |
| 收稿时间： | 2019-09-27 |
Study on chemical constituents from seeds of Trigonella foenum-graecum |
| |
| LIU Fen-yun,ZHANG Dong-li,HOU Wen-bin and TANG Sheng-an. Study on chemical constituents from seeds of Trigonella foenum-graecum[J]. Chinese Traditional and Herbal Drugs, 2020, 51(1): 31-35 |
| |
| Authors: | LIU Fen-yun ZHANG Dong-li HOU Wen-bin TANG Sheng-an |
| |
| Affiliation: | Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China;Tianjin Second People''s Hospital, Tianjin Institute of Hepatology, Tianjin 300192, China,Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China,Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin 300192, China and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China |
| |
| Abstract: | Objective To research the chemical constituents from Trigonella foenum-graecum. Methods The chemical constituents were separated and purified by sephadex LH-20, silica gel, semi-prepared HPLC and other chromatography techniques. Their structures were elucidated by their physicochemical properties and NMR data. Results Six steroidal saponins and flavonoids (1-6) were isolated from the ethanol extracts of T. foenum-graecum and identified as 22-methoxy-trigoneoside IIb (1), gitogenin (2), diosgenin (3), luteolin (4), cynaroside (5), and luteolin-7-O-rutinoside (6). Conclusion Compound 1 is a new compound, and compounds 5 and 6 are obtained for the first time from T. foenum-graecum. |
| |
| Keywords: | Trigonella foenum-graecum L. steroidal saponin 22-methoxy-trigoneoside IIb cymaroside luteolin-7-O-rutinoside |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
|
点击此处可从《中草药》下载全文 |
|
