| 乳腺癌ER、PR、p53、Her-2表达与新辅助化疗有效率的关系 |
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| 引用本文： | 刘瑞磊,吕伟明,卫洪波,王佳妮,黄勇,李杰,廖艺.乳腺癌ER、PR、p53、Her-2表达与新辅助化疗有效率的关系[J].中华普通外科学文献（电子版）,2008,2(2). |
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| 作者姓名： | 刘瑞磊 吕伟明 卫洪波 王佳妮 黄勇 李杰 廖艺 |
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| 作者单位： | 1. 510000,广州,中山大学附属第三医院乳腺甲状腺外科
2. 中山大学附属第一医院乳腺外科 |
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| 摘 要： | 目的探讨乳腺癌患者ER、PR、p53、Her-2的表达及其与新辅助化疗有效率的关系。方法采用免疫组化的方法检测178例乳腺癌新辅助化疗患者化疗前ER、PR、p53、Her-2的表达情况,观察新辅助化疗的效果。结果178例乳腺癌新辅助化疗病例中,ER、PR、p53阴性率、Her-2过度表达率分别为33.15、23.60%、60.67%、35.39%。ER(+)组与ER(-)组、PR(+)组与PR(-)组、p53(+)组与p53(-)组化疗有效率差异均有统计学意义(P<0.05),Her-2过度表达组与非过度表达组化疗有效率差异无统计学意义(P>0.05)。结论ER、PR、p53阴性的乳腺癌病人对化疗更敏感,化疗后获益更多,ER、PR、p53可作为乳腺癌新辅助化疗(TE或CET方案)敏感性的预测指标。
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| 关 键 词： | 乳腺癌 新辅助化疗 ER PR p53 Her-2 |
Relationship between expression of ER,PR, p53, Her-2 and the effective rate of neoadjuvant chemotherapy in breast cancer |
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| LIU Rui-lei,LV Wei-ming,WEI Hong-bo,WANG Jia-ni,HUANG Yong,LI Jie,LIAO Yi.Relationship between expression of ER,PR, p53, Her-2 and the effective rate of neoadjuvant chemotherapy in breast cancer[J].Chinese Journal of General Surgery(Electronic Version),2008,2(2). |
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| Authors: | LIU Rui-lei LV Wei-ming WEI Hong-bo WANG Jia-ni HUANG Yong LI Jie LIAO Yi |
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| Abstract: | Objective To investigate the relationship between the expressions of ER, PR, p53 and Her-2 with the effective rate of neoadjuvant chemotherapy for breast cancer. Methods Expression of ER, PR, p53 and Her-2 in breast cancer of 178 patients received neoadjuvant chemotherapy were detected by immunohistochemical method before chemotherapy. Results Among the 178 cases of neoadjvant chemotherapy , the percentage of negative for ER, PR, p53 and over expression for Her-2 were 33.15%, 23.60%, 60.67%, 35.39% respecti... |
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| Keywords: | ER PR p53 Her-2 |
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