| 血脂康胶囊的体外抗肿瘤作用 |
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| 引用本文： | 杨钟,赵君贤,张英鸽.血脂康胶囊的体外抗肿瘤作用[J].中医杂志,2008,49(11):1019-1022. |
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| 作者姓名： | 杨钟 赵君贤 张英鸽 |
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| 作者单位： | 1. 中国人民解放军军事医学科学院毒物药物研究所,北京市海淀区太平路27号,100850;内蒙古农业在学动物科学与医学学院
2. 中国人民解放军军事医学科学院毒物药物研究所,北京市海淀区太平路27号,100850 |
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| 摘 要： | 目的 研究血脂康胶囊的体外抗肿瘤作用及其对化疗药物氟尿嘧啶(5-Fu)抗肿瘤作用的影响. 方法 采用四甲基偶氮唑盐(MTT)法对血脂康单用及其与5-Fu合用后对人肝癌细胞HepG2、乳腺癌细胞MCF-7和自血病细胞HL-60的抑制率进行检测. 结果 血脂康(2.56mg/ml、0.64mg/ml、0.16mg/ml、0.04mg/ml、0.01mg/ml)对HepG2、MCF-7和HL-60肿瘤细胞的抑制作用呈剂量依赖性,其IC50分别为14.057mg/ml、19.859mg/ml和27.771mg/ml;不同浓度的血脂康(0.64mg/ml、0.16mg/ml、0.04mg/ml、0.01mg/ml、0.0025mg/ml)合并5-Fu(0.24mg/ml)对3种人癌细胞的抑制率均显著高于单用5-Fu(0.24mg/ml).结论 血脂康对体外培养的癌细胞具有显著抑制作用,并可显著增强化疗药物5-Fu的抗肿瘤作用.
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| 关 键 词： | 血脂康 洛伐他汀 肿瘤 增效 |
Anti-neoplastic Effect of Xuezhikang in vitro |
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| YANG Zhong,ZHAO Jun-xian,ZHANG Ying-ge.Anti-neoplastic Effect of Xuezhikang in vitro[J].Journal of Traditional Chinese Medicine,2008,49(11):1019-1022. |
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| Authors: | YANG Zhong ZHAO Jun-xian ZHANG Ying-ge |
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| Institution: | YANG Zhong1,2,ZHAO Jun-xian1,ZHANG Ying-ge1(1.Institute of Toxicology , Pharmacology,Academy of Military Medical Sciences,Beijing 100850,2.College of Animal Science , Veterinary Medicine,Inner Mongolia Agricultural University) |
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| Abstract: | Objective To study the anti-neoplastic effect of Xuezhikang (Regulate blood-fat) Capsule in vitro and its influence on the chemotherapeutic drug 5 Fluorouracil (5-Fu).Methods Using MTT method to measure the inhibition rate of Xuezhikang Capsule used simply,5-Fu used simply and Xuezhikang Capsule with 5-Fu together on HepG2,MCF-7 and HL-60 cells.Results The inhibitory action of Xuezhikang Capsule(2.56,0.64,0.16,0.04,0.01 mg/ml) on HepG2,MCF-7 and HL-60 cells was dose-dependent and the IC50 was 14.057,19.859 ... |
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| Keywords: | Xuezhikang (Regulate blood-fat) Capsule Lovastatin Cancer Enhancement |
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