Biochemical Markers of Bone Turnover in Camurati–Engelmann Disease: A Report on Four Cases in One Family |
| |
Authors: | M V Hernández P Peris N Guañabens L Alvarez A Monegal F Pons A Ponce J Muñoz-Gómez |
| |
Institution: | (1) Department of Rheumatology, Metabolic Bone Disease Unit, Hospital Clínic i Provincial, Villarroel 170, 08036 Barcelona, Spain, ES;(2) Department of Clinical Biochemistry, Metabolic Bone Diseases Unit, Hospital Clínic i Provincial, University of Barcelona, Spain, ES;(3) Department of Nuclear Medicine, Metabolic Bone Diseases Unit, Hospital Clínic i Provincial, University of Barcelona, Spain, ES |
| |
Abstract: | Moderate increases in ``classical' biochemical markers of bone turnover have been described only in some patients with Camurati–Engelmann
disease. However, the determination of the following ``new' markers has not been previously performed: serum osteocalcin
(BGP), bone alkaline phosphatase (BAP), carboxyterminal propeptide of type I procollagen (PICP), aminoterminal propeptide
of type I procollagen (PINP), tartrate-resistant acid phosphatase (TRAP), telopeptide carboxyterminal of type I collagen (ICTP),
urinary pyridinoline (PYR), crosslinked N-telopeptides of type I collagen (NTX), and Crosslaps (CL). Such a determination
may improve the evaluation of the disease activity. To evaluate the usefulness of biochemical markers of bone turnover reflecting
Camurati–Engelmann disease activity we measured the levels of all these markers in four affected patients. The results were
compared with bone scintigraphic indices of disease activity. Except for PICP and TRAP, bone formation and resorption markers
were abnormal in all patients and were related to bone scan indices of disease activity. Among the markers of bone formation
PINP, BAP, and BGP showed the highest values, whereas NTX and CL were the most sensitive markers of bone resorption. These
results suggest that the determination of NTX or CL, and PINP or either BAP and BGP, associated with bone scan evaluation,
provides the best assessment of Camurati–Engelmann disease activity.
Received: 14 June 1996 / Accepted: 31 December 1996 |
| |
Keywords: | : Bone remodeling — Progressive diaphyseal dysplasia |
本文献已被 SpringerLink 等数据库收录! |
|