小儿结节性硬化症的临床及颅脑CT表现

目的 评价颅脑CT在小儿结节性硬化症诊断中的价值。方法 回顾性分析经临床CT共同确诊的39例小儿结节性硬化症的颅脑CT表现。结果 39例小儿结节性硬化症CT平扫表现为颅内钙化或/和非钙化结节，发生于室管膜下39例（100%），皮质或皮质下15例（38.5%），脑白质12例（30.8%），脑实质内可见孤立的斑片状钙化11例(28.2%），双侧脑室轻度增大21例（53.8%）。结论 小儿结节性硬化症的颅内结节多发生于双侧脑室外侧壁室管膜下，CT平扫对颅内高密度或钙化结节具有高度的特异性，是诊断小儿结节性硬化的首选方法。

Clinical and CT manifestations of tuberous sclerosis in children

Objective To evaluate role of cerebral CT in diagnosis of tuberous sclerosisin children. Methods 39 children with tuberous sclerosis diagnosed by clinical data andCT were retrospectively analyzed. Results 3 9 cases displayed intracranial calcificationand/or non-calcified tubercles, situating in subendyma(39 cases, accounting for 100%),cortex or subcortex (15 cases, 38.5%), white matter(12 cases, 30.8%). There wassolitary calcification patches in parenchyma (11 cases, 28.2%), and 21 cases showedslightly enlarged bilateral ventricles (21 cases, 53.8%). Conclusion Intracranialtubercles of tuberous sclerosis in children often take place under ependymal layer ofouter wall of brain ventricles. Unenhanced CT is highly specific for high-density orcalcified tubercles, serving as a top choice in diagnosis of tuberous sclerosis.