Pharmacotherapeutic interventions for cocaine abuse. Matching patients to treatments |
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Authors: | T R Kosten |
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Affiliation: | Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. |
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Abstract: | Cocaine abuse treatment has begun to use a variety of adjunctive pharmacotherapies. These medications have been used for both acute crash symptoms and long-term prevention of relapse. A phasic model of recovery was integrated with a patient typology to formulate guidelines for using these rapidly evolving pharmacotherapies. The phases are crash, with-drawal, and extinction, and the patient typology includes psychiatric vulnerability and severity of cocaine abuse as contributors to the neuroadaptation that requires pharmacological amelioration. These guidelines address five issues: whom to treat, when to treat, what treatments are available, where to initiate and maintain treatment, and how to match patients to treatment options. |
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