| 脑心综合征发生机制的实验研究 |
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| 引用本文： | 许志强,蒋晓江,陈曼娥,王景周,刘娟.脑心综合征发生机制的实验研究[J].脑与神经疾病杂志,2002,10(6):327-329. |
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| 作者姓名： | 许志强 蒋晓江 陈曼娥 王景周 刘娟 |
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| 作者单位： | 400042,重庆,第三军医大学大坪医院神经内科三病区 |
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| 基金项目： | 重庆市卫生局重点资助项目(2001～2003) |
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| 摘 要： | 目的:观察脑出血条件下神经肽Y(NPY)活性变化及其在脑心综合征发生机制中的作用。方法:动态监测大鼠脑出血过程中血浆及脑于NPY活性变化、血清心肌酶谱(CK-MB)变化以及大鼠心电图的改变。结果:脑出血后心电图异常率为80％,大鼠脑内血肿开始形成的6小时血浆及脑干NPY活性、血清CK-MB均显著升高,并以脑出血24小时血肿高峰期时最为显著,随后逐渐下降。结论:脑出血时常伴有心电图异常、血清CK-MB改变,中枢及外周神经肽Y含量升高可能参与脑心综合征的发生发展。
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| 关 键 词： | 脑心综合征 神经肽Y 心电图 心肌酶谱 |
| 文章编号： | 1006-351X(2002)06-0327-03 |
| 修稿时间： | 2002年6月11日 |
Experimental study of mechanism of Cerebral-Cardiac Syndrome |
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| XU Zhi-qiang,JIANG Xiao-jiang,CHEN Mane,et al Third.Experimental study of mechanism of Cerebral-Cardiac Syndrome[J].Journal of Brain and Nervous Diseases,2002,10(6):327-329. |
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| Authors: | XU Zhi-qiang JIANG Xiao-jiang CHEN Mane Third |
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| Institution: | XU Zhi-qiang,JIANG Xiao-jiang,CHEN Man~e,et al Third Department of neurology,Daping Hospital,Third Military Medical University,Chongqing 400042 |
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| Abstract: | Objective: To observe the chang of neuropeptide Y(NPY)during cerebral hemorrhage(ICH) and discuss its role on cerebral-cardeac syndrome (CCS). Methods: We observed the changes of NPY activity of serum and brain-stem, changes of serum CK-MB and electrocardiogram(ECG). Results: The ECG abnormality rate was 80% in ICH. NPY activity of serum and brainstem, serum CK-MB obviously increased during the time of intracerebral hematoma formation at 6h, and became significant during the peak time of intracerebral hematoma formation at 24h, then gradually decreased. Conclusion: ICH often had abnormal ECGs and CK-MB changes. The enhanced activity of central and peripheral NPY may play an important role on the mechanism of Cerbral-Cardiac Syndrome. |
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| Keywords: | Cerebral-Cardiac Syndrome neuropeptide Y electrocardiogram myocardium enzyme |
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