前列地尔联合甲钴胺治疗糖尿病周围神经病变的疗效观察

目的观察前列地尔联合甲钴胺治疗糖尿病周围神经病变（DPN）的疗效。方法将100例DPN患者随机分成2组,各50例,对照组采用甲钴胺肌内注射,治疗组在对照组用药基础上加用前列地尔静脉滴注,2周后对比2组疗效。结果治疗组改善DPN患者临床症状的总有效率为90%,对照组为64%,差异有统计学意义（P〈0.01）;周围神经传导速度均有明显改善,但治疗组优于对照组（P〈0.05）。结论前列地尔联合甲钴胺治疗DPN可明显提高治疗效果。

Clinical Analysis on Alprostadil Combined with Mecobalamin for Diabetic Peripheral Neuropathy

Objective ] To observe the therapeutic effects of alprostadil combined with mecobalamin for diabetic peripheral neuropathy. Methods] 100 patients with diabetic peripheral neuropathy were randomly divided into control group （meeobalamine intramuscular injection） and treatment group （ alprostadil intravenous drip on the basis of control group treatment （. After 2 weeks, the therapeutic effects were compared between the two groups. Results ] Results ] There was significant difference in the total effective rate of improving clinical symptoms between treatment group （90%） and control group （64% ） （ P 〈 0. 01 ）. The peripheral nerve conduction velocity in two groups all had improved, but that in treatment group was better than that in control group significantly （ P 〈 0. 05）. Conclusion] Conclusion] Alprostadil combined with mecobalamin can improve the curative effect of diabetic peripheral neuropathy obviously.