| 胃癌患者血浆游离氨基酸含量变化 |
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| 引用本文： | 曹伟新 尹浩然. 胃癌患者血浆游离氨基酸含量变化[J]. 上海交通大学学报(医学版), 1989, 9(4): 312-314 |
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| 作者姓名： | 曹伟新 尹浩然 |
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| 作者单位： | 上海第二医科大学附属瑞金医院普外科(曹伟新，尹浩然，朱寿柱)，上海第二医科大学附属瑞金医院普外科(林言箴) |
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| 摘 要： | 应用LKB 4400氨基酸自动分析仪,测定23例进展期胃癌患者的血浆游离氨基酸含量,将其与国内正常成人值相比较,发现前者有明显改变。1.支链氨基酸及丙氨酸含量均显著升高(P<0.001～0.05);2.组氨酸含量有不同程度的减少(P<0.001～<0.05);3.酪氨酸量轻度增加(P>0.05)。提示胃癌患者血浆游离氨基酸含量的变化可视为恶性肿瘤时氨基酸代谢紊乱的一种反映。
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| 关 键 词： | 胃癌 血浆游离氨基酸 支链氨基酸 |
Changes of Plasma Free Amino Acid Concentration in Patients with Gastric Cancer |
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| Cao Weixing,et al. Changes of Plasma Free Amino Acid Concentration in Patients with Gastric Cancer[J]. Journal of Shanghai Jiaotong University:Medical Science, 1989, 9(4): 312-314 |
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| Authors: | Cao Weixing et al |
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| Affiliation: | Cao Weixing,et al Department of Surgery,Rui jin Hospital,Shanghai Second Medical university,Shanghai |
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| Abstract: | The concentration of plasma free amino acid was measured in 23 cases of advance gastric cancer by using LKB 4400 amino acid analyser. Several obvious changes were noticed as compared with the respective values in norrnal adults: (1) There was a significant elevation of the concentration of BCAAs and alanine in patients with gastric cancer(P<0.001-0.05). (2) A decrease in the concentration of histidine was universally observed, but with wide variation (P<0.001->0.05). (3) There was a slight increase in the concentration of tyrosine (P>0.05). The above results distorted metabolic states of the patients. Since the values observed in the different types of cancer differ significantly, they could be used as a reference in compounding various amino acid Composition for total parenteral nutrition (TPN) and enteral nutrition |
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| Keywords: | gastric cancer plasma free amino acid branched chain amino acid |
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