难治性肺部感染的细菌学分析

目的分析难治性细菌性肺部感染的病原菌和药敏试验. 方法对1999年10月～2002年6月间,难治性细菌性肺部感染患者,采用经纤维支气管镜单套管防污染毛刷(PSB),采集下呼吸道标本进行半定量培养和药敏试验. 结果共培养细菌86株,其中革兰阴性杆菌(GNB)66株(76.7%),革兰阳性球菌(GPC)16株(18.6%),主要是铜绿假单胞菌、恶臭假单胞菌、嗜麦芽寡养单胞菌和金黄色葡萄球菌,病原菌存在广泛耐药性. 结论引起难治性肺部感染的病原菌以耐药假单胞菌属和金黄色葡萄球菌为主,应重视病原学诊断.

Bacteriological Analysis of Intractable Pneumonia

OBJECTIVE To analyze the pathogens and the drug-sensitivity results in intractable bacterial pneumonia. METHODS The specimens collected with protected specimen brush(PSB) from patients with intractable bacterial pneumonia between Oct 1999 and Jun 2002 were cultured and tested. RESULTS A total of 86 strains were cultured, 66(76.7%) were Gram-negative bacilli(GNB) and 16(18.6%) were Gram-positive cocci(GPC), The main kinds of pathogens were Pseudomonas aeruginosa, P. putida, Stenotrophomonas maltophilia and Staphylococcus aureus. The drug-sensitivity tests showed that these pathogens were multiresistant. CONCLUSIONS The major sorts of pathogens caused intractable bacterial pneumonia were drug-resistant Pseudomonas sp and S. aureus. More attention should be paid to pathogenic diagnosis.