单纯HGV感染急性肝炎患者的临床与病理研究

目的 通过对一组急性ＨＧＶ感染患者的肝组织病理和临床资料分析，探讨庚型肝炎病毒感染的致病性，方法 采用免疫组织化学技术对５９例不明原因包性肝炎患者的肝组织，进行乙、丙和庚型肝炎病毒怕检测，部分病例经原位杂交证实。结果 ＨＧＶＮＳ５怕的检出率为（５７．６％〈３４／５９），其中２０直组织中ＨＢｓＡｇ和／或ＨＣＶＮＳ３Ａｇ同时阳性ＩＨＧＶ合并感染组），ＨＧＶ阳性信号主要位于肝细胞浆内。ＨＧＶ单纯感染病例

Clinico-pathological study on acute hepatitis of HGV infection alone

Aim To investigate the pathogenicity of HGV infection.Methods Fifty nine cases of liver biopsies from patients with acute hepatitis of unknown etiology were examined for HBsAg and HCV NS3Ag as well as HGV NS5Ag by immunohistochemical technique and partly identified by in situ hybridization.Results HGV NS5Ag was detected in 34 out of 59 cases, including 20 cases with positive HBsAg and or HCV NS3Ag simultaneously (the HGV coinfected group).The positive signals of HGV antigen were located mainly in cytoplasm of hepatocytes. There were no differences between the group of the HGV infection alone(14 cases) and the HGV coinfected group (P>005).Conclusion HGV is a hepatotropic virus and its infection could cause acute hepatitis.