| 天然抗角蛋白自身抗体与银屑病关系的实验研究 |
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| 引用本文： | 李承新,刘玉峰,迟素敏,万业宏,高天文. 天然抗角蛋白自身抗体与银屑病关系的实验研究[J]. 中国皮肤性病学杂志, 2002, 16(3): 148-149,152 |
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| 作者姓名： | 李承新 刘玉峰 迟素敏 万业宏 高天文 |
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| 作者单位： | 1. 第四军医大学西京医院皮肤科,陕西,西安,710032
2. 第四军医大学生理学教研室,陕西,西安,710032 |
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| 基金项目： | 国家“1 0 35”工程资助课题 (96 - 90 1 - 0 1 - 38) |
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| 摘 要： | 目的 探讨天然抗角蛋白自身抗体 (antikeratinautoantibody ,AKautoAb)与银屑病的关系及AKautoAb在银屑病中的作用和意义。方法 应用自银屑病患者血清和鳞屑洗脱液内纯化的AKautoAb ,在体外观察其对培养角质形成细胞DNA合成及细胞代谢的影响。结果 银屑病患者血清内可纯化出AKautoAb ,但其纯化量明显低于正常人 ,鳞屑洗脱液中亦可纯化出AKautoAb ;纯化的AKautoAb在体外能抑制角质形成细胞的代谢活性 (P <0 .0 5 )。结论 存在于银屑病患者血清和鳞屑内的AKautoAb可能是一种具有保护作用的继发性反应。
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| 关 键 词： | 抗角蛋白自身体抗 角质形成细胞 银屑病 实验研究 |
| 文章编号： | 1001-7089(2002)03-0148-02 |
Experimental Studies on Relationship between Antikeratin Autoantibodies and Psoriasis |
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| LI Cheng xin,LIU Yu feng,CHI Su min,et al Departement of Dermatology,Xijing Hospital,the Fourth Military Medical niversity,Xi'an ,China. Experimental Studies on Relationship between Antikeratin Autoantibodies and Psoriasis[J]. The Chinese Journal of Dermatovenereology, 2002, 16(3): 148-149,152 |
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| Authors: | LI Cheng xin LIU Yu feng CHI Su min et al Departement of Dermatology Xijing Hospital the Fourth Military Medical niversity Xi'an China |
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| Affiliation: | LI Cheng xin,LIU Yu feng,CHI Su min,et al Departement of Dermatology,Xijing Hospital,the Fourth Military Medical niversity,Xi'an 710032,China |
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| Abstract: | Objective To investigate relationship between antikeratin autoantibody(AK auto Ab) and psoriasis,and the biological role and significance of AK auto Abs in psoriaisis.Methods Using affinity chromatography,AK auto Abs were purified from serum and scale solution of patients with psoriasis.Influence of AK auto Abs purified were observed on DNA synthesis and cellular metabolism of keratinocyte cultured in vitro.Results AK auto Abs could be purified from serum of psoriasis patients,but their content was much lower than that in normal people.AK auto Abs could also be purified from the scale solution of patient.Purified AK auto Abs had an inhibitory effect on DNA synthesis and cellular metabolism of keratinocytes cultured in vitro.Conclusion AK auto Abs,existent in serum and scales of patients with psoriasis,may play a protective role which is a secondary reaction to psoriasis. |
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| Keywords: | Antikeratin autoantibody Keratinocyte Psoriasis |
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