多沙唑嗪控释片与苯那普利对轻中度原发性高血压疗效的对比观察

目的 :确定多沙唑嗪 (doxazosin)控释片对轻、中度原发性高血压的降压疗效及耐受性。方法 :选取 41例坐位舒张压 95～ 115mmHg( 1mmHg =0 133kPa)的轻、中度原发性高血压患者 ,随机分为多沙唑嗪控释片组 ( 4mg/d)与苯那普利 (benazepril)组 ( 10mg/d)。于安慰剂期末及治疗 2、4、6、8周测诊室血压、心率并记录症状、体征及不良反应。结果 :8周治疗总有效率 :多沙唑嗪控释片组 6 1 9% ,苯那普利组 6 5 0 %。 2组坐位血压较基础血压均明显下降 ,2组下降幅度相似。不良反应多沙唑嗪控释片组较苯那普利组少 ( 14 3%vs .45 0 % ,P <0 0 5 )。 2组均无体位性低血压发生。结论 :多沙唑嗪控释片 4mg ,每日 1次 ,治疗轻、中度原发性高血压患者具有疗效肯定 ,耐受性好 ,不良反应少的特点 ;经过 8周的治疗证明 ,服用 4mg多沙唑嗪控释片的降压效果与服用 10mg的苯那普利片相同

A Comparative Trial of the Efficacy of Doxazosin Retard and Benazepril Treatment of Mild to Moderate Essential Hypertension

Objective: To investigate the efficacy and tolerability of doxazosin retard (DOXR). Methods: A prospective randomized, double blind antihypertensive therapy study was carried out in 41 patients with mild to moderate hypertension. After 2-weeks of cessation of hypertensive drugs or 2-weeks of placebo run-in period, the patients were randomly given either DOXR 4 mg or benazepril (BEN) 10 mg once a day for 8 weeks. Blood pressure, heart rate, clinical safety, specific symptoms were examined at baseline and at 2,4,6,and 8 weeks. Laboratory examination was performed at baseline and at 8 weeks. Results: At the end of 8 weeks, no statistical difference was found in response rates (SeDBP<90 mmHg,or a decrease of at least 10 mmHg) between DOXR group (61.9%) and BEN group (65.0%). SeSBP/SeDBP was not significantly decreased at 2,4,6,8 weeks in both groups (p>0.05). The incidence of adverse effects such as dizziness and palpitation was 14.3% and 45.0%,respectively. No postural hypotension was found in both groups. Conclusion: DOXR 4 mg daily is as effective as and much more tolerated than BEN 10 mg daily in Chinese patients with essential hypertension.