| 肝素修饰人血SOD在家兔血液中的稳定性及在小鼠体内的抗凝血作用 |
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| 引用本文： | 金生浩,吴梧桐.肝素修饰人血SOD在家兔血液中的稳定性及在小鼠体内的抗凝血作用[J].中国药科大学学报,1994(5). |
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| 作者姓名： | 金生浩 吴梧桐 |
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| 作者单位： | 中国药科大学生物化学教研室 |
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| 摘 要： | 报道了肝素修饰的人血ＳＯＤ在家兔血液中的稳定性及在小鼠体内的抗凝血作用。与天然ＳＯＤ相比，修饰酶在血液中的稳定性明显提高，半衰期由天然ＳＯＤ的１０ｍｉｎ延长至６２ｍｉｎ，同时修饰酶仍保持肝素的抗凝血作用。
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| 关 键 词： | 超氧化物歧化酶 修饰酶 半衰期 抗凝血 肝素 |
Study on the Stability of Heparin Modified Human Erythrocyte SOD in Rabbit Blood and Its Anticoagulative Effect in Mice |
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| Jin Shenghao,Wu Wutong.Study on the Stability of Heparin Modified Human Erythrocyte SOD in Rabbit Blood and Its Anticoagulative Effect in Mice[J].Journal of China Pharmaceutical University,1994(5). |
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| Authors: | Jin Shenghao Wu Wutong |
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| Abstract: | The stability of heparin modified human erythrocyte superoxiue dismutase in rabbit blood and its anticoagulative effect were studied.The results indicated that the stability of modified enzyme in rabbit blood had ramarkable improvement in contrast to native enzyme. The half-life of modified enzyme was 62 minutes,while that of native enzyme 10 minutes. In addition, the modiried enzyme still retained the anticoagulative effect of heparin. |
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| Keywords: | Superoxide dismutase Modified enzyme Half-life Anticoagulation |
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