381例药品不良反应报告分析

目的：分析医院药物不良反应（ADR）的发生情况，为临床提供合理用药信息。方法：对本市某医院呈报的2006年度381例不良反应病例进行分析评价。结果：ADR的发生与性别、年龄、剂型及给药途径、用药品种密切相关。所累及的器官系统以皮肤及附件最常见。其次为胃肠道反应。较严重的为过敏性休克；引起ADR的品种以抗茼药为主，其次为中药制剂，剂型以注射剂为主，多由静脉滴注引起。结论：应重视ADR工作的重要性，加强合理用药，减少不良反应的发生。

Analysis of 381 Adverse Drug Reaction Reports

Objective： To investigate and analyze the occurrence of ADR to provide scientific information for a rational use of drugs in clinical practice. Method： 381 adverse drug reaction case reports were analyzed and evaluated during 2006 in Loudi. Result： The occurrence of ADR was closely related to sex, age, dosage form, route of administration and variety of medicine. System-organ damages were common in skin and appendixes, gastro-intestinal damages were the next. The most serious was allergic shock. Most ADRS were caused by antibacterial drugs and the next, by traditional Chinese medicine preparations. The pharmaceutical dosage forms causing ADR were mainly injectable preparations, and the most ADRs were caused by intravenous drip. Conclusion： It is important to pay close attention to ADR reports, strengthen ra- tional use of drugs and decrease the reappearance of ADRs.