| 肝硬化巨脾切除对免疫功能的影响 |
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| 引用本文： | 吴厚慧,徐鹿平,刘凤强,李莉,杨清萍,陈家林,万默各,陈治横,芮奕峰,侯岩松.肝硬化巨脾切除对免疫功能的影响[J].肝胆胰外科杂志,2000,12(2):80-82. |
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| 作者姓名： | 吴厚慧 徐鹿平 刘凤强 李莉 杨清萍 陈家林 万默各 陈治横 芮奕峰 侯岩松 |
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| 作者单位： | 浙江省嘉兴市第一医院,314000 |
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| 摘 要： | 目的：探讨肝硬化巨脾切除对免疫功能的影响。方法：对２６例肝硬化巨脾患者切脾主前、术手两周、术手半年、一年分别抽取周围静脉血测定ＩｇＧ，ＩｇＡ，ＩｇＭ，Ｃ３，Ｃ４，ＴＮＦ，ｓＩＬ－２Ｒ，ＣＤ３＾＋，ＣＤ４＾＋，ＣＤ８＾＋，ＣＤ４＾＋／ＣＤ８＾＋，用Ｆ检验作出显著性测定。结果：ＩｇＧ，ＩｇＡ，ＩｇＭ，Ｃ３，Ｃ４，ＴＮＦ，ｓＩＬ－２Ｒ，ＣＤ８＾＋切脾差异均无意义（Ｐ〉０．０５），ＣＤ３＾＋，ＣＤ４＾＋，
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| 关 键 词： | 肝硬化 脾肿大 脾切除术 免疫功能 |
| 修稿时间： | 2000-03-01 |
Changes in immunologic function a fter splenectomy in patients with cirrhosis and splenomegaly |
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| WU Hou hui,XU Lu ping,LIU Feng qiang. et al . Depatment of Surgery,First Hospital of Jiaxing,Zhejiang Province,Jiaxing.Changes in immunologic function a fter splenectomy in patients with cirrhosis and splenomegaly[J].Journal of Hepatopancreatobiliary Surgery,2000,12(2):80-82. |
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| Authors: | WU Hou hui XU Lu ping LIU Feng qiang Depatment of Surgery First Hospital of Jiaxing Zhejiang Province Jiaxing |
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| Institution: | WU Hou hui,XU Lu ping,LIU Feng qiang. et al . Depatment of Surgery,First Hospital of Jiaxing,Zhejiang Province,Jiaxing 314000 |
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| Abstract: | Objective: To investigate the effects of splenectomy on immunologic function in patients with cirrhosis and splenomegaly.Methods: Various essay including IgG, IgA, IgM, C 3 ,C 4 ,TNF,sIL-2R, CD + 3 ,CD + 4 ,CD + 8 ,CD + 4 /CD + 8 of the peripheral venous blood in 26 cirrhotic patients preoperatively and 2 weeks postoperatively , Follow up examination were also done half a year and one year postoperatively.Results: The results were analyzed by F-test. Except for the significantly higher levels of CD + 3 ,CD + 4 , CD + 4 /CD + 8 after splenectomy than they were preoperatively (P<0.05), all other indices have no significant change (P>0.05).Conclusion: Splenectomy in patients with cirrhosis has no significant adverse effects on the humoral and cellular immunity, which justifies the resection of pathologic spleen. |
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| Keywords: | cirrhosis splenomegaly splenectomy immunologic function |
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