| CD4^＋CD25^＋FOXP3^＋调节性T细胞在与原因不明反复自然流产的相关性研究 |
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| 引用本文： | 杨滨,夏欣一,周玉春,付鹿,崔英霞,许晓风,黄宇烽.CD4^＋CD25^＋FOXP3^＋调节性T细胞在与原因不明反复自然流产的相关性研究[J].中国优生与遗传杂志,2009,17(4):13-15. |
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| 作者姓名： | 杨滨 夏欣一 周玉春 付鹿 崔英霞 许晓风 黄宇烽 |
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| 作者单位： | 杨滨(南京军区南京总医院解放军检验医学研究所生殖遗传室,南京,210002;南京师范大学生命科学学院,南京,210046);夏欣一,周玉春,崔英霞,黄宇烽(南京军区南京总医院解放军检验医学研究所生殖遗传室,南京,210002);付鹿,许晓风(南京师范大学生命科学学院,南京,210046)
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| 摘 要： | 目的探讨外周血中CD4＋CD25＋FOXP3＋调节性T细胞（CD4^＋CD25^＋FOXP3^＋Tr）在原因不明反复自然流产（URSA）发病中的作用。方法应用三色荧光标记流式细胞术检测21例原因不明反复自然流产妇女（URSA组）、20例正常妊娠妇女（正常对照组）外周血中CD4^＋CD25^＋FOXP3^＋Tr及T细胞亚群水平的表达情况。结果URSA组妇女外周血中CD4^＋CD25^＋FOXP3^＋Tr表达率为（1.36±0.61）%,明显低于正常对照组（5.59±1.02）%,两组比较差异显著（P（0.05）,但两组相比较外周血中T细胞亚群CD3^＋、CD4^＋、CD8^＋、CD4^＋/CD8^＋水平无显著差异（P（0.05）。结论原因不明反复自然流产的发生可能与患者外周血中CD4^＋CD25^＋FOXP3^＋Tr数量减少有关。
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| 关 键 词： | 原因不明反复自然流产 CD4+CD25+ FOXP3 流式细胞术 |
Study on the relationship between CD4+ CD25+ FOXP3+ regulatory T cells and unexplained recurrent spontaneous abortion |
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| Institution: | YANG Bin, et al. (Department of Clinical Experiment Medicine, Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Commond, PLA, Nanjing University School of Medicine, Nanjing 210002 ) |
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| Abstract: | Objective ： To investigate the relationship between CD4^＋CD25^＋ FOXP3^＋ regulatory T cells （ CD4^＋ CD25^＋ FOXP3^＋ Tr） and unexplained recurrent spontaneous abortion （URSA）. Methods： The peripheral blood samples were taken from 21 URSA women and 12 normal pregnancy women. The percentage of CD4^＋ CD25^＋ FOXP3^＋ Tr in peripheral blood were measured by double - label flow cytometric analysis. Results： There were no apparent differences in T lymphocyte subset ratio in peripheral blood between URSA women and normal pregnancy women. However the expression frequency of CD4^＋ CD25^＋ FOXP3^＋ Tr was decreased significantly （ P 〈0. 05） in URSA women （ 1. 36±0. 61 ） % ] than that in normal pregnancy women （5.59 ± 1.02） % ]. Conclusion： The results suggest that down - regulation of CD4^＋ CD25^＋ FOXP3^＋ Tr may be associated with URSA. |
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| Keywords: | CD4 CD25 FOXP3 |
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