Activity of ethylene oxide in the mouse sperm morphology test |
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| Authors: | Lucia Regina Ribeiro Daisy Maria Fávero Salvadori Carlos Alberto Bragança Pereira Willy Beçak |
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| Affiliation: | (1) Laboratório de Toxicologia e Genética Toxicológica, Departamento de Patologia e Clínicas, Escola de Medicina Veterinária, Universidade Federal da Bahia, Av. Ademar de Barros, 500, Ondina, 40000 Salvador, Bahia, Brazil;(2) Serviço de Genética, Instituto Butantan, São Paulo, Brazil;(3) Instituto de Matemática e Estatística da Universidade de São Paulo, São Paulo, Brazil |
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| Abstract: | Inhaled ethylene oxide induced an increased frequency of abnormal sperm cells in mice when the animals were treated at 200 and 400 ppm (6 h per day; 5 days) in three stages of cell development: spermatozoa, spermatid and preleptotene spermatogonial cells. These results suggest that sperm head morphology changes can be induced by interference of ethylene oxide with spermatogenesis, which, depending on the stage of the treated germ cells, may be correlated with the mutagenic potential of this chemical agent. |
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| Keywords: | Ethylene oxide Mouse sperm Morphology test |
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