| CXCL12/CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展 |
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| 引用本文： | 杨晨,姚阳.CXCL12/CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展[J].现代肿瘤医学,2009,17(8). |
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| 作者姓名： | 杨晨 姚阳 |
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| 作者单位： | 上海市交通大学附属第六人民医院肿瘤内科,上海,200233 |
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| 基金项目： | 上海市市级医学慢性病综合防治项目资助 |
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| 摘 要： | 研究发现趋化因子CXCL12(Stromal-derived factor-1,SDF-1)和受体CXCR4chemokine (C-X-C motif) receptor 4]广泛表达于组织和器官上,相关的研究发现其与前列腺癌细胞的黏附、侵袭、增殖和生存有关,并认为其在前列腺癌骨转移的发生中发挥重要作用.通过阐明CXCL12/CXCR4生物学轴和前列腺癌骨转移之间的关系,从而寻找有助于疾病治疗的新途径.
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| 关 键 词： | 前列腺癌 骨转移 |
Advance in the research of the mechanism of CXCL12/ CXCR4 axis induced osseous metastasis of prostate cancer |
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| YANG Chen,YAO Yang.Advance in the research of the mechanism of CXCL12/ CXCR4 axis induced osseous metastasis of prostate cancer[J].Journal of Modern Oncology,2009,17(8). |
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| Authors: | YANG Chen YAO Yang |
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| Abstract: | CXCL12(stromal-derived factor-1,SDF-1) and its receptor CXCR4(chemokine (C-X-C motif) receptor 4)were demonstrated to be widely expressed in a broad array of tissues and organs.Recent studies suggested that CXCL12/ CXCR4 axis was related to the adhesion,invasion,proliferation and survival of prostate cancer cells,and played an important role in bone metastasis.Elucidating the relationship between the CXCL12/ CXCR4 axis and the development of bone lesion of prostate cancer is helpful to find a new way to treat the disease. |
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| Keywords: | CXCL12 CXCR4 CXCL12 CXCR4 Prostate cancer Bone metastasis |
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