Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia |
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Authors: | Ashour Mohamed Edrada RuAngelie Ebel Rainer Wray Victor Wätjen Wim Padmakumar K Müller Werner E G Lin Wen Han Proksch Peter |
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Affiliation: | Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universit?t Düsseldorf, Universit?tsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany. |
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Abstract: | Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalides F (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, HMBC) and mass spectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahalalide F toward the MCF7 human mammary carcinoma cell line. |
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