乳酸脱氢酶及a-羟丁酸脱氢酶对早期白血病筛查及预后评估

目的：通过对乳酸脱氢酶及a-羟丁酸脱氢酶的数值变化,筛查早期白血病及对急性白血病的诊断提供依据,并对预后做出评估。方法：采用全自动生化分析仪测定80例门诊、住院患者（非白血病组）及70例急性白血病患者于初发/复发（primary/recurrence group）、完全缓解（CR）时血清中乳酸脱氢酶（sLDH）和a-羟丁酸脱氢酶（HBDH）的水平,筛查白血病,及与对照组进行比较分析。结果：非白血病组筛查出2例白血病,AL患者的血清LDH及HBDH水平在初发/复发组比对照组和CR组活性升高,差异有统计学意义（P〈0.05）。结论：血清LDH及HBDH活性升高有助于急性白血病诊断并对急性白血病病情变化做出评估。

Lactate Dehydrogenase and a-Hydroxybutyrate Dehydrogenase in Early Leukemia Screening and Prognosis

Objective：By lactate dehydrogenase and a-hydroxybutyrate dehydrogenase values change,the early screening of acute leukemia and provide the basis for the diagnosis of leukemia,and to assess prognosis.Methods：80 cases of outpatient,inpatient（nonAL group） and 70 cases of acute leukemia（acute leukemia,AL）,The serum levels of LDH and HBDH in primary/recurrence group,CR group of acute leukemia were tested by means of full automated biochemistry analyzer and compared with control group.Results：Screening out non-group 2 cases of leukemia leukemia,The LDH and HBDH levels increased,in the primary/recurrence acute leukemia group.There were differences in LDH and HBDH levels among the primary/recurrence group,the control group and the CR group（P〈0.05）.Conclusion： The LDH and HBDH levels increased,in patients with acute leukemia.This is helpful to diagnose correctly and an assessment of changes in conditions of acute leukemia.