舌下含服粉尘螨滴剂治疗变应性鼻炎临床疗效观察

目的评价舌下含服粉尘螨滴剂治疗变应性鼻炎1年的疗效及安全性。方法采用前后对照,比较72例粉尘螨变应性鼻炎患者在接受1年舌下含服粉尘螨滴剂治疗前、后的体征及症状评分、鼻炎相关生活质量评分,评价舌下含服粉尘螨滴剂治疗的疗效,并统计不良反应发生率,评估其安全性。结果治疗1年后,72例患者症状评分较治疗前均明显减少(P<0.05),有效率76.4%;鼻炎相关生活质量较治疗前明显改善(P<0.05);其中5例(6.9%)出现局部不良反应,4例(5.6%)出现全身轻微不良反应,未出现全身严重不良反应。结论舌下含服粉尘螨滴剂是治疗变应性鼻炎的一种有效方法,且具有较高的安全性。

Sublingual with dermatophagoides farinae drops extract for allergic rhinitis

Objective To evaluate the efficacy and safety of sublingual with dermatophagoides farinae drops extract for the treatment of allergic rhinitis for 1 year.Methods 72 patients with allergic rhinitis caused by dermatophagoides farinae were enrolled in this self-contrast study.Clinical efficacy was evaluated by signs and symptoms scores and life quality scores after one year of sublingual immunotherapy and compared with pre-treatment scores.Results A clinically significant reduction in signs and symptoms scores in these 72 patients compared with those of pre-treatment was found（P〈0.05）.The effective rate was 76.4%,All items of quality of life were improved significantly（P〈0.05）.5 local adverse reactions including oral/sublingual swelling,sublingual tinglingnumbness and oral itching and 5 slight systemic adverse reactions occurred in total subjects,while no fatal systemic reaction occurred.Conclusion Sublingual with dermatophagoides farinae drops extract is an effective treatment for patients suffering from allergic rhinitis,individualization of dosage is recommended to improve tolerance and security.