临床分离铜绿假单胞菌的标本、科室分布及耐药性分析

目的 分析铜绿假单胞菌的临床感染特点及其耐药性,为临床防止感染及合理用药提供依据.方法 对2009年10月至2011年6月我院门诊和住院患者的各类送检标本进行病原菌培养与鉴定,药敏试验采用K-B纸片扩散法;并对铜绿假单胞菌临床分离株标本分布及耐药性进行分析.结果 从送检标本中分离到的铜绿假单胞菌182株,痰及咽拭子标本占120株(65.9%);主要分布在重症监护病房(76株,占41.8%)、呼吸科(26株,14.3%).头孢哌酮/舒巴坦、亚胺培南的耐药率较低,其中头孢哌酮/舒巴坦耐药率最低(15.9%).结论 铜绿假单胞菌多重耐药情况严重,临床应根据近期监测结果及药敏结果合理选用抗菌药物.

Distribution and antibiotic resistance of pseudomonas aeruginosa isolated from clinic

Objective To analyze the clinical infection characteristics and drug resistance of pseudo- monas aeruginosa, in order to provide a basis to prevent infection and rational drug use. Methods Patients with outpatient and inpatient routine specimens between october 2009 and june 2011 were culture and identifica- tion of pathogenic bacteria, and antimierobial susceptibility tests were using ＂KB disk diffusion method, and sam- ples of clinical isolates of Pseudomonas aeruginosa distribution and drug resistance for statistical analysis. Re- sults 182 pseudomonas aeruginosa were isolated from different kinds of samples, accounting for 120 sputum samples （65.9%）,mainly in the ICU（41.8% ）, the lowest resistance to cefoperazone/sulbactam （15.9%）, secondly was imipenem （24. 7% ）. Conclusion Pseudomonas aeruginosa is multiple antibiotic resistance, and clinical testing should be based on rational choice of antimicrobial azent.