| 槲皮素通过抑制己糖激酶的表达促进结肠癌SW480细胞凋亡 |
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| 引用本文： | 卢创新,崔瑶,李晓燕,周云.槲皮素通过抑制己糖激酶的表达促进结肠癌SW480细胞凋亡[J].中国实用医药,2012,7(8):58-59. |
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| 作者姓名： | 卢创新 崔瑶 李晓燕 周云 |
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| 作者单位： | 河南省郑州大学人民医院肿瘤内科,450003 |
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| 摘 要： | 目的观察槲皮素对SW480细胞增殖和凋亡的影响并探讨其机制。方法采用流式细胞检测技术检测槲皮素诱导人结肠癌SW480细胞的凋亡能力;应用免疫细胞化学技术检测细胞中己糖激酶蛋白的表达。结果槲皮素以浓度依赖性的方式诱导结肠癌SW480细胞的凋亡并下调己糖激酶蛋白的表达。结论槲皮素通过抑制己糖激酶的表达来促进结肠癌SW480细胞凋亡。
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| 关 键 词： | 结肠癌 槲皮素 凋亡 己糖激酶 |
The quercetin induce SW480 cells apoptosis through downregulation of hexokinase |
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| LU Chuang-xin,CUI yao,LI Xiao-Yan,ZHOU Yun.The quercetin induce SW480 cells apoptosis through downregulation of hexokinase[J].China Practical Medical,2012,7(8):58-59. |
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| Authors: | LU Chuang-xin CUI yao LI Xiao-Yan ZHOU Yun |
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| Institution: | .Oncology department of henan people＇hospital of Zhengzhou University,Zhengzhou,450003,Henan Province,China |
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| Abstract: | Objective Investigate the apoptogenic activities of quercetin on SW480 cells.Methods Annexin V-FITC/PI stained fluorescence-activated cell sorter（FACS） was used to detcted the apotosis rate,Immunocytochemistry was used to examine cellular localisation and hexokinase protein levels.Results quercetin produced dose-dependent inhibition of SW480 cell growth and induced its apoptosis,the expressions of hexokinase proteins were down regulated by quercetin.Conclusion The quercetin induce SW480 cells apoptosis through downregulation of hexokinase |
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| Keywords: | Colon carcinoma Quercetin Apoptosis Hexokinase |
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