纤维蛋白原检测在判断冠状动脉粥样硬化性心脏病病变程度中的意义

目的 探讨纤维蛋白原 (Fibrinogen,Fg)水平在冠状动脉硬化性心脏病患者病变严重程度中的差异.方法 收集我院2006年1月至2008年2月,经冠状动脉造影确诊为冠状动脉粥样硬化性心脏病者96例,轻度病变33例,中度病变28例,重度病变35例.所以,患者行血浆纤维蛋白原检测,判断冠状动脉粥样硬化不同程度间纤维蛋白原的差别.结果 轻度病变组纤维蛋白原为(3.53±1.03)g/L,中度病变组为(4.01±1.23)g/L,重度病变组为(6.01±1.66)g/L.重度病变组纤维蛋白原水平最高,差别有统计学意义(P<0.0001).结论 冠心病患者的血浆纤维蛋白原水平与病变的严重程度程相关性,其升高水平可以反映冠状动脉狭窄程度.

Fibrinogen in Coronary Atherosclerotic Herat Disease

Objective To evaluage the diffevence of Fibrinogen in patients with coronary atherosclerot- ic herat disease（CAHD）. Methods Fom January 2006 to February 2008, 96 patients with coronary heart dis- ease were evaluated retrospectively. Among the 96 patients, severe lesions in 35 cases, mild lesion 28 cases and slight lesions in 33 cases diagnosed by coronary angiography （CAG）. All of the patients were tested for Fibrino- gen to determine the severity difference between the three groups. Results The level of Fibrinogen between the slight disease, mild disease and severe disease group were 3.53±1.03 g/L, 4. 01±1.23 g/L and 6. O1 ±1. 66 g/L, respectively. There was statistically significant difference between the three groups （ P 〈 0. 0001 ）. Con- eluston Plasma Fibrinogen levels were related to the degree of coronary artery stenosis.