| ki67、p504s、p63联合检测在前列腺癌中的临床意义研究 |
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| 引用本文： | 林海利,郑周达,陈森期,许振强,庄志明,张朝贤,邹宗楷,沈洪武. ki67、p504s、p63联合检测在前列腺癌中的临床意义研究[J]. 医学综述, 2008, 14(11): F0002-F0002 |
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| 作者姓名： | 林海利 郑周达 陈森期 许振强 庄志明 张朝贤 邹宗楷 沈洪武 |
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| 作者单位： | 福建医科大学附属漳州市医院泌尿外科,福建,漳州,363000 |
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| 基金项目： | 福建省卫生厅青年科研项目 |
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| 摘 要： | 目的探讨p504s、p63和ki67在前列腺癌中的表达情况及联合检测的临床意义。方法应用免疫组织化学SP法检测70例前列腺增生和28例前列腺癌中p504s、p63和ki67的表达情况。结果前列腺癌患者p504s、p63、ki67表达阳性率均高于前列腺增生患者,差异均有显著性(P<0.01)。p504s、p63和ki67单独检测的灵敏度分别为89.3%、78.6%和67.8%,特异度分别为92.9%、88.6%和94.3%。而三者联合检测的灵敏度分别为92.8%、82.1%、75%,特异度分别为92.9%、85.7%、95.7%。结论p504s、p63、ki67可作为前列腺癌的肿瘤标记物,协助临床上前列腺癌的诊断;联合检测可提高前列腺癌的诊断准确率。
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| 关 键 词： | ki67 p504s p63 前列腺癌 |
| 文章编号： | 1006-2084(2008)11-C2-02 |
| 修稿时间： | 2008-05-22 |
The Clinical Significance of ki67、p504s and p63 Antigene in Prostate Cancer |
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| LIN Hai-li,ZHENG Zhou-da,CHEN Sen-qi,XU Zhen-qiang,ZHUANG Zhi-ming,ZHANG Chao-xian,ZHOU Zong-kai,SHEN Hong-wu. The Clinical Significance of ki67、p504s and p63 Antigene in Prostate Cancer[J]. Medical Recapitulate, 2008, 14(11): F0002-F0002 |
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| Authors: | LIN Hai-li ZHENG Zhou-da CHEN Sen-qi XU Zhen-qiang ZHUANG Zhi-ming ZHANG Chao-xian ZHOU Zong-kai SHEN Hong-wu |
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| Affiliation: | LIN Hai-li,ZHENG Zhou-da,CHEN Sen-qi,XU Zhen-qiang,ZHUANG Zhi-ming,ZHANG Chao-xian,ZHOU Zong-kai,SHEN Hong-wu.(Department of Urology,The Affiliated Zhangzhou City Hospital of Fujian Medical University,Zhangzhou 363000,China) |
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| Abstract: | Objective To study the expression of p504s,p63 and ki67 in prostate cancer and their bilogical significane.Methods Immunohistochemistry S-P method was used to detect the expression of p504s,p63 and ki67 in 28 prostate cancer and 70 normal prostate tissue specimem.Results Their sensitivity respectively was 89.3%,78.6%,67.8% and their specificity was 92.9%,88.6%,94.3%.When they were examined together,Their sensitivity respectively was changed into 92.8%,82.1%,75%,and their specificity 92.9%,85.7%,95.7%.Conclu... |
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| Keywords: | ki67 p504s p63 Prostate carcinoma |
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