盐酸齐拉西酮和氟哌啶醇对精神分裂症认知灵活性的疗效比较

目的:探讨比较盐酸齐拉西酮和氟哌啶醇对精神分裂症患者认知灵活性的疗效.方法:对50例服用齐拉西酮维持治疗与50例服用氟哌啶醇维持治疗的精神分裂症患者进行12个月随访,采用威斯康星卡片分类(WCST)和连线测验(Trailing Making)评估患者的认知灵活性.结果:维持治疗12个月末齐拉西酮组和氟哌啶醇组的WCST测验中的总分类次数、错误数、持续错误数、非持续错误数以及连线测验各指标(连线A、B时间,A、B错误数和A、B犯规数)均显著下降(P＜0.05),并且齐拉西酮组的持续错误数减分率显著高于氟哌啶醇组(P＜0.05).治疗后,两组连线测验成绩减分率差异无统计学意义(P＞0.05).结论:齐拉西酮较氟哌啶醇更有益于改善精神分裂症患者的认知灵活性.

Effect of ziprasidone hydrochloride and haloperidol on cognitive flexibility in schizophrenia

AIM:To explore the long-time efficacy of ziprasidone hydrochloride in the treatment of cognitive flexibility in schizophrenia.METHODS:50 cases of patients continuously treated with ziprasidone hydrochloride and 50 cases of patients treated with haloperidol were included in the 12 months follow-up study.Cognitive flexibility was tested with Wisconsin card sorting test(WCST)and Trail Making Test.RESULTS:At the time of 12 months,all the scores of total tdal,sorts,perseverative errors and random errors on WCST and all target of Trail Making Test were significantly decreased in the two groups of patients(P＜0.05 or P＜0.01):but the decreased rate of perseverative errors on WCST of ziprasidone hydrochloride group were significantly higher than that of Haloperidol group(P＜0.01).CONCLUSION:Compare with Haloperidol,ziprasidone hydrochloride has a better efficacy in the long-time treatment of cognitive flexibility in schizophrenia.