| 奥氮平与氯氮平治疗精神分裂症的双盲对照研究 |
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| 引用本文： | 王长虹,冯砚国,王来海. 奥氮平与氯氮平治疗精神分裂症的双盲对照研究[J]. 上海精神医学, 2002, 14(3): 143-145 |
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| 作者姓名： | 王长虹 冯砚国 王来海 |
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| 作者单位： | 453002,新乡医学院第二附属医院精神卫生教研室 |
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| 摘 要： | 目的评价奥氮平治疗精神分裂症的有效性及安全性。方法采用随机双盲对照试验．奥氮平组30例(男13例，女17例)，剂量范围5～20mg／d；氯氮平组31例(男16例，女15例)，剂量范围为25～400mg／d．结果奥氮平治疗精神分裂症的显效率为60％，有效率为77％；而氯氮平的显效率为55％，有效率为74％，两药的疗效无显著性差异。奥氮平的副反应较少，未发现白血胞减少及直立性低血压。结论奥氮平是一有效而安全的非典型抗精神病药物，对精神分裂症阴性阳性症状均有效。
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| 关 键 词： | 奥氮平 氯氮平 精神分裂症 双盲对照法 副反应 药理作用 |
A double-blind randomized controlled study of olanzapine and clozapine on treatment of schizophrenia |
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| Wang Changhong,Feng Yanguo,Wang Laihai. A double-blind randomized controlled study of olanzapine and clozapine on treatment of schizophrenia[J]. Shanghai Archives of Psychiatry, 2002, 14(3): 143-145 |
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| Authors: | Wang Changhong Feng Yanguo Wang Laihai |
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| Abstract: | Objectives: To evaluate the efficacy and safety of olanzapine in treatment of schizophrenia. Method: A randomized controlled study was conducted to compare the efficacy and safety of olanzapine and clozapine. 61 patients with schizophreina were divided into two groups. 30 cases were treated with olanzapine in a regimen of 5-20 mg/d. 31 cases were treated with clozapine in a regimen of 25-400 mg/d. Results: The response rate in olanzapine group was 77%, whereas 75% in clozapine group. Conclusion: Olanzapine is effective against the positive and negative symptoms of schizophrenia with signifcantly fewer side effect. |
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| Keywords: | Olanzapine Clozapine Schizophrenia Effectiveness |
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