Peritoneal fluid concentrations of cefoxitin in children during appendectomy |
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Authors: | Hagith Nagar Stephen A. Berger Bertie Hammar Alfred Gorea |
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Affiliation: | (1) Departments of Pediatric Surgery, Tel-Aviv Medical Center, and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel;(2) Departments of Microbiology, Tel-Aviv Medical Center, and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel;(3) Department of Microbiology, Ichilov Hospital, 6 Weitzman Street, 64239 Tel-Aviv, Israel |
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Abstract: | Fifteen children underwent appendectomy following administration of a single i.v. dose of cefoxitin (20 mg/kg). The mean cefoxitin concentration of peritoneal fluid prior to resection of the appendix was 9.3 ± 2.9 g/ml, representing 264% ± 47% of the concurrent serum concentration. All samples of appendiceal tissue contained less than 5.0 g/g. Peritoneal cefoxitin levels exceeded the usual minimal inhibitory concentration of Staphylococcus aureus and Escherichia coli, but were indadequate for Bacteroides fragilis. We recommend use of a higher cefoxitin dose (40 mg/kg) for the preoperative prophylaxis of appendectomy in children. |
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Keywords: | Appendix Cefoxitin, metabolism Peritonitis |
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