26例抗着丝点抗体阳性分析

目的:提高临床对抗着丝点抗体的认识.方法:回顾分析了26例抗着丝点抗体阳性患者临床资料.结果:26例抗着丝点抗体阳性患者中系统性硬化症10例(38.4%),系统性红斑狼疮4例(15.4%),干燥综合症和类风湿关节炎分别3例(11.5%),混合结缔组织病、仅有雷诺现象各2例(7.7%),CREST综合征和不明原因肝脏疾病各1例(3.8%).着丝点抗体可同时出现其它自身抗体.结论:抗着丝点抗体可出现在多种疾病中,着丝点抗体并非CREST综合征的特异性抗体,抗着丝点抗体阳性患者最多见临床症状为雷诺现象(53.8%),其次为皮肤硬化(34.6%).

Clinical analysis of anticentromere antibodies positive in 26 cases

Objective:To comprehend the clinical significance of anticentromere antibodies(ACA)positive in patients.Methods:A total of 26 patients with positive ACA were studied retrospectively.Results:There were 10 patients with systemic sclerosis(38.4%),4 patients with systemic lupus erythematosus(15.4%),3 patients with Sjogren's syndrome and rheumatoid arthritis(11.5%)respectively,2 patients with mixed connective tissue disease and Raynaud phenomenon(7.7%)respectively,1 patient with CREST syndrome and 1 patient with liver disease of unknown causes (3.8%).ACA and other autoantibodies were present in serum at the same time.Conclusion:ACA is found in many diseases.ACA is not specific for CREST syndrome.The major clinical characteristics of the patients correlated with ACA are Raynaud phenomenon(53.8%)and scleroderma(34.6%).