| Memory CD8＋ T cell differentiation in viral infection： A cell for all seasons |
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| 引用本文： | Radziewicz H,Uebelhoer L,Bengsch B,Grakoui A. Memory CD8＋ T cell differentiation in viral infection： A cell for all seasons[J]. World journal of gastroenterology : WJG, 2007, 13(36): 4848-4857. DOI: 10.3748/wjg.v13.i36.4848 |
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| 作者姓名： | Radziewicz H Uebelhoer L Bengsch B Grakoui A |
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| 作者单位： | Emory Vaccine Center and Department of Microbiology and Immunology Department of Medicine Emory University School of Medicine Atlanta GA 30322 United States,Emory Vaccine Center and Department of Microbiology and Immunology Department of Medicine Emory University School of Medicine Atlanta GA 30322 United States,Department of Medicine University Hospital Freiburg Freiburg 79106 Germany,Emory Vaccine Center and Department of Microbiology and Immunology Department of Medicine Emory University School of Medicine Atlanta GA 30322 United States |
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| 基金项目： | NIH National Center for Research Resources K12 RR017643 and NIH K08 AI072191 (HR),the National Institutes of Health through the Grand Challenges in Global Health Initiative, Cancer Research Institute Investigator Award, Woodruff Health Sciences Fund, Yerkes Research Center Base Grant RR-00165 and NIH AI070101 (AG) |
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| 摘 要： | Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus- specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.
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| 关 键 词： | 丙型肝炎 病毒感染 记忆T细胞表型 分化 |
| 收稿时间： | 2007-06-26 |
Memory CD8+ T cell differentiation in viral infection: a cell for all seasons |
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| Radziewicz Henry,Uebelhoer Luke,Bengsch Bertram,Grakoui Arash. Memory CD8+ T cell differentiation in viral infection: a cell for all seasons[J]. World journal of gastroenterology : WJG, 2007, 13(36): 4848-4857. DOI: 10.3748/wjg.v13.i36.4848 |
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| Authors: | Radziewicz Henry Uebelhoer Luke Bengsch Bertram Grakoui Arash |
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| Affiliation: | 1. Emory Vaccine Center and Department of Microbiology and Immunology; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States
2. Department of Medicine, University Hospital Freiburg, Freiburg 79106, Germany |
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| Abstract: | Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus- specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system. |
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| Keywords: | Viral infection Hepatitis C virus Memory T cell phenotype Differentiation |
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