| 复合透皮促渗剂对氨氯地平的促渗透作用 |
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| 引用本文： | 郭衍坤,贺新华,梅武轩,周云,鲍翠玉. 复合透皮促渗剂对氨氯地平的促渗透作用[J]. 医药导报, 2003, 22(1): 18-19 |
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| 作者姓名： | 郭衍坤 贺新华 梅武轩 周云 鲍翠玉 |
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| 作者单位： | 湖北咸宁医学院内科教研室,437100 |
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| 基金项目： | 湖北省教委科研基金资助课题 (基金编号 :98A0 74) |
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| 摘 要： | 目的：研究不同透皮促渗剂对氨氯地平混悬液的体外兔皮渗透作用.方法：以30%乙醇为溶媒,分别配制含不同透皮促渗剂的氨氯地平饱和混悬液,采用自制改良Franz’s扩散池测量其对体外兔皮的促渗透作用.结果：促渗剂对氨氯地平均有促渗透作用,不同透皮促渗剂促透作用的大小顺序为：丙二醇＜油酸＜阿佐恩＜阿佐恩＋丙二醇＜油酸＋丙二醇.与不含促渗剂相比,油酸＋丙二醇渗透系统稳态透皮渗透速率约为不含促渗剂的2.7倍.结论：复合透皮促渗剂对氨氯地平有良好的促渗透作用.
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| 关 键 词： | 氨氯地平 透皮促渗剂,复合 |
| 文章编号： | 1004-0781(2003)01-0018-02 |
| 修稿时间： | 2002-04-29 |
Effect of Compound Penetration Enhancers on Permeability of Amlodipine Through Rabbit Skin |
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| GUO Yan-kun,HE Xin-hua,MEI Wu-xuan,ZHOU Yun,BAO Cui-yu. Effect of Compound Penetration Enhancers on Permeability of Amlodipine Through Rabbit Skin[J]. Herald of Medicine, 2003, 22(1): 18-19 |
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| Authors: | GUO Yan-kun HE Xin-hua MEI Wu-xuan ZHOU Yun BAO Cui-yu |
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| Abstract: | Objective:To study the effect of compound penetration enhancers on the in vitro permeability of amlodipine from the suspension through rabbit skin. Method:30% ethyl alcohol is used as solvent and mixed with amlodapine saturated suspension containing different kinds of penetration enhancers. Then its permeability effect through rabbit skin was determined by using the Franz's type diffusion cell. Results:The penetration rates of amlodipine increased by enhancers in the following order : propylene glycol
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| Keywords: | Amlodipine Penetration enhancer compound |
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