| 聚乳酸/壳聚糖多孔支架材料的生物学性能评价 |
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| 引用本文： | 李立华,丁珊,周长忍.聚乳酸/壳聚糖多孔支架材料的生物学性能评价[J].生物医学工程学杂志,2003,20(3):398-400. |
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| 作者姓名： | 李立华 丁珊 周长忍 |
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| 作者单位： | 暨南大学,生命科技学院生物材料研究室,广州,510630 |
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| 基金项目： | 国家“973”资助项目 (G19990 5 43 0 6)，“863”资助项目(2 0 0 1AA62 5 0 5 0 )，广东省“十五”重大专项资助项目 (A3 0 2 0 2 0 10 4) |
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| 摘 要： | 通过过敏试验、热原试验和细胞培养与毒性试验，对聚乳酸(PLA)／壳聚糖多孔支架材料进行了生物学评价。结果显示，聚乳酸／壳聚糖复合三维多孔材料均呈阴性，符合ISO 10993-1标准，细胞能在材料表面更好的贴附和生长。所以，本材料具有良好的生物相容性，可以用作细胞支架材料植入体内。
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| 关 键 词： | 聚乳酸 壳聚糖 多孔支架材料 生物学 生物相容性 |
Preparation and Biological Evaluation of PLA/Chitosan Composite Materials |
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| Lihua Li,Shan Ding,Changren Zhou.Preparation and Biological Evaluation of PLA/Chitosan Composite Materials[J].Journal of Biomedical Engineering,2003,20(3):398-400. |
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| Authors: | Lihua Li Shan Ding Changren Zhou |
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| Institution: | Biomaterials Research Lab, Chemistry Department, Jinan University, Guangzhou 510630. |
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| Abstract: | Hypersusceptibility test, pyrogen test, cell cultivation, and toxicity examination were applied in the biological evaluation of the polylatic acid (PLA)/chitosan composite materials. The results indicated that all the materials were negative, conforming to the ISO10993-1. The cell could grow well on the surface of the materials. So the PLA/chitosan composite materials have good biocompatibility and can be planted in the body as scaffolds. |
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| Keywords: | PLA/Chitosan Composite materials Biological evaluation |
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