贲门癌术后反流性食管炎66例的药物治疗

目的：探讨治疗贲门癌术后反流性食管炎的药物选择及临床疗效的评估。方法：对66例贲门癌术后反流性食管炎首先口服雷尼替丁150mg／次，2次／d，吗丁啉10－20mg/次，3次／d（或西沙必利5－10mg／次，3次／d），硫铝糖1g／次，3次／d。无效者改用奥美拉唑，剂量为20－40mg／次，1次／d。结果：联合治疗后有51．5％（34／66）的患者症状消失或明显缓解；无效者改用奥美拉唑治疗后有93．8％（30／32）的患者症状消失或明显缓解。结论：在选择治疗贲门癌术后反流性食管炎的药物时，首先可选用雷尼替丁、吗丁啉（或西沙必利）、硫糖铝联合治疗，无效者改用奥美拉唑，可增加贲门癌术后反流性食管炎的疗效。

Medicine treatment for 66 cases with reflux esophagitis resulting from postoperative cardiac carcinoma

Purpose:To observe medicine in the treatment of reflux esophagitis resulting from postoperative cardiac carcinoma. Methods:66 patients with reflux esophagitis resulging from postoperative cardiac carcinoma firstly were treated with ranitidine-motilium/cisapridc-sucralfatc combined regimen and the doses were 150 mg(bid),10-20 mg(tid),5-10 mg(tid),1 g(tid),respectively. The patients with no efficacy with combined regimen were treated ulteriorly with omeprazole, the dose was 20-40 mg(qd). Results:The clinical disappearing or improvement was attained by 51.6%(34/66) in patients treated with combined regimen, and by 93.8%(30/32) in patients (with no efficacy with combined ergimen) treated with omeprazole. Conclusions:Omeprazole could be efficacious for patients with reflux esophagitis resulting from postoperative cardiac carcinoma with no efficacy with ranitidinc-motilium/cisapridc-ulccrlmin combined regimen. Omeprazole as preferred therapy for reflux esophagitis resulting from postoperative cardiac carcinoma should be tested.