映山红总黄酮的镇咳平喘作用与毒性研究

目的研究映山红总黄酮的镇咳平喘作用和毒性反应。方法采用急性毒性试验确定药效剂量,以慢性气管炎的主要症状—咳、喘为药效学指标,采用小鼠氨水引咳法、整体动物药物引喘法研究映山红总黄酮的镇咳平喘作用。结果映山红总黄酮(0.064 g/kg)对致咳小鼠具有显著的镇咳作用,映山红总黄酮(0.038 g/kg)对致喘豚鼠具有显著的平喘作用,同时,映山红粗提物及总黄酮对实验动物具有不同程度的毒性反应。结论映山红总黄酮在发挥药效的同时,不可忽视其毒性反应。

Study on Antitussive, Antiasthmatic Effects and Toxicity of Total Flavanoid of Rhododendron simsii Planch

Objective To study antitussive,antiasthmatic effects and toxicity of total flavanoid of Rhododendron simsii Planch(TFR).MethodsEffective dosage was decided with acute toxicity experiment.As major symptoms of chronic bronchitis,cough and asthma were studied on TFR with experiments of mice and Guinea pigs with ammonia and histamine,respectively.ResultsTFR(0.064,0.038g/kg) had obvious antitussive,antiasthmatic effects on mice and guinea pigs with ammonia and histamine,respectively.And Rhododendron simsii Planch extracts,total flavanoid had different degree of toxicity reactions to laboratory animal.ConclusionToxicity of TFR shouldn't be neglected when it has effects.