| 牙本质磷蛋白在人牙胚发育中的原位杂交研究 |
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| 引用本文： | 张敬雷,汪平,吴补领,逄键梁,郭鹏,郭维拉,田宇. 牙本质磷蛋白在人牙胚发育中的原位杂交研究[J]. 牙体牙髓牙周病学杂志, 2003, 13(2): 70-72 |
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| 作者姓名： | 张敬雷 汪平 吴补领 逄键梁 郭鹏 郭维拉 田宇 |
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| 作者单位： | 第四军医大学口腔医学院,陕西,西安,710032 |
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| 基金项目： | 国家自然科学基金资助项目 (3980 0 15 5 ) |
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| 摘 要： | 目的：观察牙本质磷蛋白（DPP）基因在人牙胚组织发育过程中的表达，探讨其在牙齿发育中的作用。方法：采用原位杂交的方法，检测帽状期、钟状期牙胚组织DPPmRNA的表达。结果：人牙胚帽状期、钟状早期均未检测到DPPmRNA的表达，在钟状晚期前期牙本质形成时成牙本质细胞、前成釉细胞中呈阳性表达。结论：牙本质磷蛋白基因的转录具有明显的的时空特异性，它可能在牙体硬组织的形成中起重要的作用。
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| 关 键 词： | 牙本质磷蛋白 牙胚 原位杂交 |
| 文章编号： | 1005-2593(2003)02-0070-03 |
| 修稿时间： | 2002-08-23 |
Dentin phosphophoryn mRNA expression in developing embryonic human teeth |
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| ZHANG Jing-lei,WANG Ping,WU Bu-ling,et al. Dentin phosphophoryn mRNA expression in developing embryonic human teeth[J]. Chinese Journal of Conservative Dentistry, 2003, 13(2): 70-72 |
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| Authors: | ZHANG Jing-lei WANG Ping WU Bu-ling et al |
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| Abstract: | AIM:To observe the gene expression of dentin phosphophoryn (DPP) in developing embryonic human teeth.METHODS: DPP mRNA expression was studied by method of in situ hybridizationRESULTS:Hybridization signals were uniquely detected for DPP mRNA in odontoblasts and preameloblasts during later bell stage but not in the cap stage and early bell stage.CONCLUSION:The expression of DPP has temprospacial characters, not only played important role during dental mineralization, but also possible participated in signal transduction during odontoblasts and ameloblasts differentiation. |
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| Keywords: | dentin phosphophoryn teeth germ human in situ hybridization |
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